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FLASH GENE
Symbol KLK13 contributors: mct - updated : 02-04-2020
HGNC name kallikrein-related peptidase 13
HGNC id 6361
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
of KLK6 and KLK13 in ovarian cancer compared to normal ovarian tissues
tumoral     --over  
significantly increased in invasive cancers relative to normal ovaries
tumoral     --over  
in breast cancer with good prognostic
tumoral     --over  
in several common salivary gland tumors
tumoral     --over  
in esophageal squamous cell carcinoma (ESCC) were associated with cell proliferation and correlated with tumor progression, advanced cancer stage, and poor prognosis
tumoral     --low  
in bladder tumors and is correlated with disease aggressiveness, including higher tumor stage and grade
tumoral     --low  
in oral squamous cell carcinoma (OSCC) cell lines
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • tumor biomarker capable of predicting a favorable outcome for gastric cancer patients ,
  • potential biomarkers that can significantly predict prognosis in terms of recurrence-free survival and overall survival in ovarian cancer
  • loss of KLK13 a potential biomarker for early detection of lymph node metastasis in OSCCs
  • KLK13 mRNA expression constitutes a novel biomarker for the prediction of overall survival in NSCLC (nonsmall cell lung cancer)
  • MUC16 and KLK13 represent independent prognostic markers for colon cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    may be therapeutic targets for treatment of ovarian cancer
    miscelleaneousdermatology 
    potential target for the treatment of skin disorders in which KLK activity is elevated
    ANIMAL & CELL MODELS