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FLASH GENE
Symbol KLK9 contributors: mct/npt - updated : 08-04-2020
HGNC name kallikrein-related peptidase 9
HGNC id 6370
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a peptidase S1 domain
    • HOMOLOGY
    Homologene
    FAMILY
  • peptidase S1 family
  • kallikrein subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    basic FUNCTION
  • new independent favorable prognostic marker for early stage, low-grade, optimally debulked ovarian cancer patients
  • may play a crucial role in promoting cancer-cell invasion in bladder tumor (Shinoda 2007)
  • KLK9 and KLK10, once activated, are unlikely to participate in further pro-KLK activation pathways, although similar to KLK1 they may activate other bioactive peptides
  • is a glycosylated chymotrypsin-like enzyme with strong preference for tyrosine over phenylalanine at the P1 cleavage position
    • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
  • enzyme activity is enhanced by Mg2+ and Ca2+, but is reversibly attenuated by Zn2+
    • protein
    cell & other
    REGULATION
    Other regulated by steroid hormones
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • urinary KLK9 might be potentially used as an indicator of hypertensive cardiac and vascular damage
  • elevations in glioblastoma KLK9 protein have utility as prognostic markers of patient survival
    • Therapy target
    ANIMAL & CELL MODELS