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FLASH GENE
Symbol KLK9 contributors: mct/npt - updated : 08-04-2020
HGNC name kallikrein-related peptidase 9
HGNC id 6370
Location 19q13.41      Physical location : 51.505.769 - 51.512.890
Synonym name
  • kallikrein-like 3
  • kallikrein 8
  • kallikrein 9
  • kallikrein-like protein 3
  • Synonym symbol(s) KLK-L3, KLK8, KLKL3, MGC50513
    EC.number 3.4.21.35
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text tightly clustered multigene family on chromosome 19q13.4
    STRUCTURE 7.08 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    regionally located clustered with kallirein gene family
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1438 - 250 - Yousef (2000)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Lymphoid/Immunetonsils   highly Homo sapiens
    Nervousbrainhindbraincerebellum  
     spinal cord    
    Reproductivefemale systemovary  highly
     male systemtestis   
     male systemseminal vesicles   
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticprogenitor cell Homo sapiens
    Lymphoid/Immuneactivated B lymphocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a peptidase S1 domain
  • HOMOLOGY
    Homologene
    FAMILY
  • peptidase S1 family
  • kallikrein subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    basic FUNCTION
  • new independent favorable prognostic marker for early stage, low-grade, optimally debulked ovarian cancer patients
  • may play a crucial role in promoting cancer-cell invasion in bladder tumor (Shinoda 2007)
  • KLK9 and KLK10, once activated, are unlikely to participate in further pro-KLK activation pathways, although similar to KLK1 they may activate other bioactive peptides
  • is a glycosylated chymotrypsin-like enzyme with strong preference for tyrosine over phenylalanine at the P1 cleavage position
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
  • enzyme activity is enhanced by Mg2+ and Ca2+, but is reversibly attenuated by Zn2+
  • protein
    cell & other
    REGULATION
    Other regulated by steroid hormones
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • urinary KLK9 might be potentially used as an indicator of hypertensive cardiac and vascular damage
  • elevations in glioblastoma KLK9 protein have utility as prognostic markers of patient survival
  • Therapy target
    ANIMAL & CELL MODELS