Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol KLK9 contributors: mct/npt - updated : 08-04-2020
HGNC name kallikrein-related peptidase 9
HGNC id 6370
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1438 - 250 - Yousef (2000)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Lymphoid/Immunetonsils   highly Homo sapiens
Nervousbrainhindbraincerebellum  
 spinal cord    
Reproductivefemale systemovary  highly
 male systemtestis   
 male systemseminal vesicles   
Respiratoryrespiratory tractlarynx  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticprogenitor cell Homo sapiens
Lymphoid/Immuneactivated B lymphocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a peptidase S1 domain
  • HOMOLOGY
    Homologene
    FAMILY
  • peptidase S1 family
  • kallikrein subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    basic FUNCTION
  • new independent favorable prognostic marker for early stage, low-grade, optimally debulked ovarian cancer patients
  • may play a crucial role in promoting cancer-cell invasion in bladder tumor (Shinoda 2007)
  • KLK9 and KLK10, once activated, are unlikely to participate in further pro-KLK activation pathways, although similar to KLK1 they may activate other bioactive peptides
  • is a glycosylated chymotrypsin-like enzyme with strong preference for tyrosine over phenylalanine at the P1 cleavage position
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
  • enzyme activity is enhanced by Mg2+ and Ca2+, but is reversibly attenuated by Zn2+
  • protein
    cell & other
    REGULATION
    Other regulated by steroid hormones
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • urinary KLK9 might be potentially used as an indicator of hypertensive cardiac and vascular damage
  • elevations in glioblastoma KLK9 protein have utility as prognostic markers of patient survival
  • Therapy target
    ANIMAL & CELL MODELS