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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

KLK5

contributors: mct/pgu - updated : 10-07-2017

HGNC name	kallikrein-related peptidase 5
HGNC id	6366

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in breast and ovarian cancer tumoral     --over   in squamous cell carcinoma of the lung tumoral     --over   in oral squamous cell carcinoma and may be implicated in malignant progression tumoral     --low   in prostate and breast cancers constitutional     --other   unregulated activities of KLK5 and KLK7 are responsible for Netherton syndrome (NS) development

Susceptibility

Variant & Polymorphism

Candidate gene	potential biomarkers for breast cancer
Marker
Therapy target
	System Type Disorder Pubmed miscelleaneous dermatology   potential target for the treatment of skin disorders in which KLK activity is elevated

ANIMAL & CELL MODELS