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FLASH GENE

Symbol

KLK5

contributors: mct/pgu - updated : 10-07-2017

HGNC name	kallikrein-related peptidase 5
HGNC id	6366

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY	peptidase S1 family
	kallikrein subfamily

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
text	keratinocyte
	in the skin, SPINK5, KLK7, and KLK5 were all found in the lamellar granule (LG) system, but were separately localized

basic FUNCTION	having trypsin, but not chymotrypsin-like, activity
	in normal skin, involved in desquamation during epidermal differentiation via proteolytic cleavage of the desmosomal cadherin component desmoglein
	key actor of the desquamation process, as the major target of SPINK5
	may play a crucial role in promoting cancer-cell invasion in bladder tumor
	as other KLKs may participate in desquamation through cleavage of desmoglein 1 and regulation by LEKTI
	exhibit trypsin-like specificity, with a strong preference for Arg at the P1 position of substrates
	may potentially promote metastatic dissemination of oral squamous cell carcinoma by promoting loss of junctional integrity through cleavage of desmoglein 1 (DSG1)
	may potentiate metastatic dissemination of oral squamous cell carcinoma by contributing to dissolution of DSG1-containing cell-cell contacts, thereby modifying epithelial cohesion
	KLK5, KLK12 are involved in the cleavage activation of human-adapted influenza virus subtypes
	KLK5, KLK7 and KLK14 are important proteases in skin desquamation

CELLULAR PROCESS

protein, degradation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	target of SPINK5
	interacting with DSG1 (KLK5 action may destabilize DSG1 structure and abolish adhesion to desmocollins on neighboring cells)
	the actions of KLK7 are tightly controlled by PI3 and SPINK5, which also inhibits KLK5, localizing protease activity to the stratum corneum
	KLK5 and KLK8 remove the N-terminal eight AAs from the proform thereby converting CCL14 to its active state
	SPINK5 tightly controls the activities of serine proteases such as kallikrein-related peptidase KLK5 and KLK7 in the epidermis

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in breast and ovarian cancer tumoral     --over   in squamous cell carcinoma of the lung tumoral     --over   in oral squamous cell carcinoma and may be implicated in malignant progression tumoral     --low   in prostate and breast cancers constitutional     --other   unregulated activities of KLK5 and KLK7 are responsible for Netherton syndrome (NS) development

Susceptibility

Variant & Polymorphism

Candidate gene	potential biomarkers for breast cancer
Marker
Therapy target
	System Type Disorder Pubmed miscelleaneous dermatology   potential target for the treatment of skin disorders in which KLK activity is elevated

ANIMAL & CELL MODELS