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last update : 20/10/2006
Symbol AMLT2
Location 7p15.2, 11p15.4
Name acute myeloid leukemia, with limited differentiation (FAB M2 and M4)
Corresponding gene HOXA9 , NUP98
Main clinical features
  • in translocation t(7;11)(p15;p13), or non-Hodgkin lymphoma with t(1;11) (q23;p15)
  • Genetic determination
    Function/system disorder
    Type malignancy
    Gene product
    Name chimeric fusion protein 5'-NUP98-HOXA9-3',see symbols
    Remark(s) A chromosomal translocation found in certain acute myeloid leukaemia (AML) patients results in fusion of the plant homeodomain (PHD) finger of a chromatin-binding protein to a common fusion partner, nucleoporin-98 (NUP98). By binding chromatin, the NUP98–PHD fusion protein—found to be a potent oncoprotein that induces AML—apparently locks developmentally important genes into an active state.