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| GENATLAS PHENOTYPE |
| last update : 20/10/2006 |
| Symbol | AMLT2 |
| Location | 7p15.2, 11p15.4 |
| Name | acute myeloid leukemia, with limited differentiation (FAB M2 and M4) |
| Corresponding gene | HOXA9 , NUP98 |
| Main clinical features |
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| Genetic determination | |
| Function/system disorder | |
| Type | malignancy |
| Gene product |
| Name | chimeric fusion protein 5'-NUP98-HOXA9-3',see symbols |
| Remark(s) | A chromosomal translocation found in certain acute myeloid leukaemia (AML) patients results in fusion of the plant homeodomain (PHD) finger of a chromatin-binding protein to a common fusion partner, nucleoporin-98 (NUP98). By binding chromatin, the NUP98–PHD fusion protein—found to be a potent oncoprotein that induces AML—apparently locks developmentally important genes into an active state. |