basic FUNCTION
| transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities in the antero-posterior axis |
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activating CYBB transcription in differentiated myeloid cells |
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maintains endothelial cells in a quiescent state by negatively regulating NFKB1 activity |
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important for normal hematopoiesis, modulating MEIS1 through CREB1 targeting ![](pubmed.jpg) |
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overexpression of HOXA9 induces IGF1R expression and subsequently promotes leukemic cell growth ![](pubmed.jpg) |
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acting as an obligate proinflammatory factor by mediating cytokine induction of E-selectin ![](pubmed.jpg) |
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major differentiation factors of the NK-cell lineage, including HOXA9, HOXA10 and ID2, were (de)regulated via polycomb repressor complex 2 (PRC2) which therefore contributes to T-cell leukemogenesis ![](pubmed.jpg) |
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an important regulatory role in cytokine induction of the EC-leukocyte adhesion molecules E-selectin and vascular cell adhesion molecule 1 ![](pubmed.jpg) |
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stimulus-dependent methylation of HOXA9 is essential for ELAM expression during the EC inflammatory response ![](pubmed.jpg) |
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HOXA9 and FLT3 signaling are individually important for the generation of lymphoid lineage precursors from multipotent hematopoietic progenitors (MPP) in bone marrow ![](pubmed.jpg) |