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FLASH GENE
Symbol HOXA9 contributors: mct/shn - updated : 09-03-2012
HGNC name homeobox A9
HGNC id 5109
Corresponding disease
AMLT2 acute myeloid leukemia, with limited differentiation (FAB M2 and M4)
Location 7p15.2      Physical location : 27.202.057 - 27.205.149
Synonym name
  • homeo box A9
  • homeodomain protein HOXA9
  • homeobox protein Hox-A9
  • homeobox protein Hox-1G
  • Synonym symbol(s) HOX1G, ABD-B, HOX1, HOX1.7, MGC1934
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 3.09 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map pter - D7S2538 - D7S2440 - HOXA9 - D7S2564 - D7S2441 - cen
    Physical map
    LOC392006 7 similar to Rpl7a protein SND1 7q31.3 similar to Rpl7a protein LOC346416 7p15.2 similar to High mobility group protein 4 (HMG-4) (High mobility group protein 2a) (HMG-2a) LOC221875 7p15.2 similar to tropomyosin 3 LOC392007 7 similar to nucleolar protein family A, member 2; component of the H/ACA snoRNP HOXA1 7p15.3 homeo box A1 HOXA2 7p15.3 homeo box A2 HOXA3 7p15.3 homeo box A3 LOC392647 7 similar to mKIAA0038 protein LOC392879 7 similar to protease (prosome, macropain) 26S subunit, ATPase 1 HOXA4 7p15.3 homeo box A4 HOXA5 7p15.3 homeo box A5 HOXA6 7p15.3 homeo box A6 LOC392880 7 similar to hypothetical protein MGC2574 HOXA7 7p15.3 homeo box A7 HOXA9 7p15.3 homeo box A9 HOXA10 7p15.3 homeo box A10 HIBADH 7p15.2 3-hydroxyisobutyrate dehydrogenase HOXA11 7p15.3 homeo box A11 HOXA11S 7p15.2 homeo box A11, antisense HOXA13 7p15.3 homeo box A13 EVX1 7p15-p14 eve, even-skipped homeo box homolog 1 (Drosophila) LOC392008 7 similar to 60S ribosomal protein L35 NSG-X 7q31 brain and nasopharyngeal carcinoma susceptibility protein LRRC4 7q31 leucine rich repeat containing 4
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2076 - 272 - -
    - - 1903 - - - -
    HOXA10-HOXA9 readthrough, non-coding RNA
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
    Reproductivefemale systemuterus  highly
    Urinarykidney   highly
    cell lineage primitive hematopoietic cells
    cell lines
    fluid/secretion
    at STAGE
    Text expressed throughout the forelimb bud at early stages
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • helix-turn-helix, DNA binding domain
  • HOMOLOGY
    interspecies ortholog to Hoxa9, Mus musculus
    ortholog to Hoxa9, Rattus norvegicus
    ortholog to HOXA9, pan troglodytes
    intraspecies homolog to hoxd9
    Homologene
    FAMILY
  • Abd-B homeobox family
  • CATEGORY regulatory , DNA associated , transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities in the antero-posterior axis
  • activating CYBB transcription in differentiated myeloid cells
  • maintains endothelial cells in a quiescent state by negatively regulating NFKB1 activity
  • important for normal hematopoiesis, modulating MEIS1 through CREB1 targeting
  • overexpression of HOXA9 induces IGF1R expression and subsequently promotes leukemic cell growth
  • acting as an obligate proinflammatory factor by mediating cytokine induction of E-selectin
  • major differentiation factors of the NK-cell lineage, including HOXA9, HOXA10 and ID2, were (de)regulated via polycomb repressor complex 2 (PRC2) which therefore contributes to T-cell leukemogenesis
  • an important regulatory role in cytokine induction of the EC-leukocyte adhesion molecules E-selectin and vascular cell adhesion molecule 1
  • stimulus-dependent methylation of HOXA9 is essential for ELAM expression during the EC inflammatory response
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text a key regulator of hematopoiesis and embryonic development
    PATHWAY
    metabolism
    signaling
    a component
  • HOXA9/MADH4 in response to TGFB stimulation to repress osteopontin gene transcription
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PBX2 and MEIS1
  • Smad4
  • CBP
  • PIM1
  • protein arginine methyltransferase 5, PRMT5
  • cell & other
    REGULATION
    inhibited by phosphorylation by PKC, impairing its DNA binding ability and inducing myeloid differentiation
    Other negatively regulated by miR-126 binding to the homeobox
    methylation by PRMT5 is essential for endothelial cell expression of leukocyte adhesion molecules
    stability of HOXA9 controled by CUL-4A ubiquitylation machinery
    ASSOCIATED DISORDERS
    corresponding disease(s) AMLT2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with NUP98 in translocation t(7;11),in acute myeloid leukemia (see AML2)
    tumoral       gain of function
    coactivated by MEIS1 in acute and chronic myelogenous leukemia and in infant acute lymphoid leukemia
    tumoral     --over  
    in acute monocytic leukemia
    tumoral     --over  
    of NUP98-HOXA9 represses myeloid-specific gene transcription, thereby contributing to differentiation block in leukemogenesis
    constitutional     --over  
    very high expression in haemopoietic cells in adults over sixty
    constitutional     --over  
    inhibits inflammatory cytokine dependent inducible expression of leukocyte adhesion molecules in endothelial cells
    tumoral   translocation    
    t(7;17)(p15;q23) with MSI2 may contribute to disease progression in chronic myeloid leukemia
    tumoral     --other  
    aberrant expression has been shown to be important to the development of leukemia
    tumoral     --over  
    of HOXA9 and HOXA10 and their essential cofactor MEIS1 in cells with the t(4;11) chromosome translocation and MLL-AF4 in acute leukemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene hypermethylated target gene in ovarian carcinogenesis
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    is required for survival in human MLL-rearranged acute leukemias and targeting HOXA9 may be a novel therapeutic option
    ANIMAL & CELL MODELS