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FLASH GENE
Symbol ZP1 contributors: mct - updated : 18-10-2017
HGNC name zona pellucida glycoprotein 1 (sperm receptor)
HGNC id 13187
Corresponding disease
OOMD1 oocyte maturation defect 1
Location 11q12.2      Physical location : 60.635.014 - 60.643.163
Synonym name
  • epididymis luminal protein 163
    • Synonym symbol(s) MGC87693, HEL163, OOMD, OOMD1
    DNA
    TYPE functioning gene
    STRUCTURE 8.15 kb     12 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 1972 - 638 - 2004 15142998
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus   highly
    Reproductivefemale systembreastmammary gland highly
     male systemtestis  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductiveoocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a conserved ZP domain, a signature domain comprised of approximately 260 amino acid (aa) residues, that has functional activity and may have a role during fertilization
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Zp1 gene
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,granule
    basic FUNCTION
  • promote acrosomal exocytosis and now establish an additional role for these components as modifiers of sperm motility
  • ZP1, ZP3, and ZP4 have been shown to bind to the capacitated human sperm, and acrosome reaction can be mediated by ZP1, ZP3, and ZP4
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ZP1 in addition to ZP3 and ZP4, binds to capacitated spermatozoa and induces acrosomal exocytosis
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) OOMD1
    Susceptibility to sterility with oocyte morphologic abnormalities
    Variant & Polymorphism other variants c.247T>C (p.W83R) and c.1413G>A (p.W471X) associated with oocyte morphologic abnormalities and sterility
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS