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FLASH GENE
Symbol ZP1 contributors: mct - updated : 18-10-2017
HGNC name zona pellucida glycoprotein 1 (sperm receptor)
HGNC id 13187
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a conserved ZP domain, a signature domain comprised of approximately 260 amino acid (aa) residues, that has functional activity and may have a role during fertilization
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Zp1 gene
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,granule
    basic FUNCTION
  • promote acrosomal exocytosis and now establish an additional role for these components as modifiers of sperm motility
  • ZP1, ZP3, and ZP4 have been shown to bind to the capacitated human sperm, and acrosome reaction can be mediated by ZP1, ZP3, and ZP4
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ZP1 in addition to ZP3 and ZP4, binds to capacitated spermatozoa and induces acrosomal exocytosis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) OOMD1
    Susceptibility to sterility with oocyte morphologic abnormalities
    Variant & Polymorphism other variants c.247T>C (p.W83R) and c.1413G>A (p.W471X) associated with oocyte morphologic abnormalities and sterility
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS