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FLASH GENE
Symbol ZNF282 contributors: npt - updated : 17-04-2009
HGNC name zinc finger protein 282
HGNC id 13076
Location 7q36.1      Physical location : 148.892.576 - 148.923.337
Synonym name
  • HTLV-I U5 Repressive Element Binding Protein 1
  • HTLV-I U5RE-binding protein 1
  • Synonym symbol(s) HUB1, HUB-1
    DNA
    TYPE functioning gene
    STRUCTURE 30.76 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC392145 7 similar to Mtr3 (mRNA transport regulator 3)-homolog; Mtr3 (mRNA transport regulator 3)-homolog (yeast) LOC392146 7 similar to 60S ribosomal protein L32 C7orf33 7q36.1 chromosome 7 open reading frame 33 LOC392147 7 similar to Huntingtin interacting protein K CUL1 7q35-q36 cullin 1 EZH2 7q35 enhancer of zeste homolog 2 (Drosophila) RNY5 7q36 RNA, Y5 small cytoplasmic (associated with Ro protein) ERP70 7q35 protein disulfide isomerase related protein (calcium-binding protein, intestinal-related) DKFZp762I137 7q36.1 hypothetical protein DKFZp762I137 LOC155054 7q36.1 hypothetical protein LOC155054 ZNF398 7q36.1 zinc finger protein 398 ZNF282 7q35-q36 zinc finger protein 282 ZNF212 7q36.1 zinc finger protein 212 LOC389594 7 similar to KIAA1285 protein NPM1P12 7q35 nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 12 KIAA1285 7q36.1 nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 12 FLJ31413 7q36.1 hypothetical protein FLJ31413 LOC392148 7 similar to KIAA1285 protein FLJ12700 7q36.1 hypothetical protein FLJ12700 KIAA1862 7q36 KIAA1862 protein EZI 7q36.1 likely ortholog of mouse zinc finger protein EZI FLJ36112 7q36.1 hypothetical protein FLJ36112 C7orf32 7q36.1 chromosome 7 open reading frame 32 LOC389595 7 hypothetical gene supported by AK127966 MGC3036 7q31-q35 hypothetical protein MGC3036 C7orf29 7q35 chromosome 7 open reading frame 29 RARRES2 7q35 retinoic acid receptor responder (tazarotene induced) 2 LOC389596 7 LOC389596 REPIN1 7q36.1 replication initiator 1 MGC33584 7q36.1 hypothetical protein MGC33584 LOC389597 7 LOC389597 LOC389598 7 similar to expressed sequence AI854703
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 3736 74.2 671 - Cheng (2005)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a KRAB-like domain exerting an activation and a new repressive domain named HUB1, repressive (HUR) domain near the N terminus
  • the N-terminal region upstream of the HUR domain may also be important for repression
  • five C terminal zinc finger motifs C2H2 type,Krüppel-like
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • playing an important role in the HTLV-I U5-mediated repression
  • transcriptional repressor
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to the U5RE - U5 Repressive Element - (TCCACCCC sequence) of human T cell leukemia virus type I,long terminal repeat
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS