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FLASH GENE
Symbol ZNF282 contributors: npt - updated : 17-04-2009
HGNC name zinc finger protein 282
HGNC id 13076
Location 7q36.1      Physical location : 148.892.576 - 148.923.337
Synonym name
  • HTLV-I U5 Repressive Element Binding Protein 1
  • HTLV-I U5RE-binding protein 1
  • Synonym symbol(s) HUB1, HUB-1
    DNA
    TYPE functioning gene
    STRUCTURE 30.76 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 3736 74.2 671 - Cheng (2005)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a KRAB-like domain exerting an activation and a new repressive domain named HUB1, repressive (HUR) domain near the N terminus
  • the N-terminal region upstream of the HUR domain may also be important for repression
  • five C terminal zinc finger motifs C2H2 type,Krüppel-like
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • playing an important role in the HTLV-I U5-mediated repression
  • transcriptional repressor
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to the U5RE - U5 Repressive Element - (TCCACCCC sequence) of human T cell leukemia virus type I,long terminal repeat
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS