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FLASH GENE

Symbol

ZFX

contributors: mct - updated : 25-10-2011

HGNC name	zinc finger protein, X-linked
HGNC id	12869

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	Xp22.11      Physical location : 24.167.761 - 24.234.372
Synonym symbol(s)	ZNF926

DNA

TYPE	functioning gene
SPECIAL FEATURE	escaping inactivation
STRUCTURE	66.61 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

Map

see PRPS2

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001178085 11 - 7740 - 805 - 2001 11214319 NM_001178086 6 - 6801 - 576 - 2001 11214319 NM_001178095 9 - 7534 - 432 - 2001 11214319 NM_001178084 8 - 7396 - 805 - 2001 11214319 NM_003410 10 - 7604 - 805 - 2001 11214319

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal acidic domain
	a putative nuclear localization signal (NLS)
	13 zinc fingers in the C terminal region

HOMOLOGY

interspecies	homolog to rattus LOC367832
	homolog to murine Zfx

Homologene

FAMILY	krueppel c2h2-type zinc-finger protein family
	zfx/zfy subfamily

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	shared transcriptional regulator of pluripotent embryonic stem cells (ESC) and hematopoietic SC (HSC),suggesting a common genetic basis of self-renewal in embryonic and adult stem cells
	regulator of hematopoietic stem cell maintenance, in B-cell development and homeostasis
	restrains the stress response and couples antigen receptor signaling to cell expansion and maintenance during B-cell development and peripheral homeostasis

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in laryngeal squamous cell carcinoma, associated with its progression

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	Zfx-deficient pluripotent embryonic SC (ESC) and hematopoietic SC (HSC)showed increased apoptosis and SC-specific upregulation of stress-inducible genes (