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FLASH GENE
Symbol ZFX contributors: mct - updated : 25-10-2011
HGNC name zinc finger protein, X-linked
HGNC id 12869
Location Xp22.11      Physical location : 24.167.761 - 24.234.372
Synonym symbol(s) ZNF926
DNA
TYPE functioning gene
SPECIAL FEATURE escaping inactivation
STRUCTURE 66.61 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
Map see PRPS2
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 7740 - 805 - 2001 11214319
6 - 6801 - 576 - 2001 11214319
9 - 7534 - 432 - 2001 11214319
8 - 7396 - 805 - 2001 11214319
10 - 7604 - 805 - 2001 11214319
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal acidic domain
  • a putative nuclear localization signal (NLS)
  • 13 zinc fingers in the C terminal region
  • HOMOLOGY
    interspecies homolog to rattus LOC367832
    homolog to murine Zfx
    Homologene
    FAMILY
  • krueppel c2h2-type zinc-finger protein family
  • zfx/zfy subfamily
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • shared transcriptional regulator of pluripotent embryonic stem cells (ESC) and hematopoietic SC (HSC),suggesting a common genetic basis of self-renewal in embryonic and adult stem cells
  • regulator of hematopoietic stem cell maintenance, in B-cell development and homeostasis
  • restrains the stress response and couples antigen receptor signaling to cell expansion and maintenance during B-cell development and peripheral homeostasis
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in laryngeal squamous cell carcinoma, associated with its progression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Zfx-deficient pluripotent embryonic SC (ESC) and hematopoietic SC (HSC)showed increased apoptosis and SC-specific upregulation of stress-inducible genes (