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FLASH GENE
Symbol ZFR contributors: mct - updated : 28-12-2018
HGNC name zinc finger RNA binding protein
HGNC id 17277
Corresponding disease
SPG71 spastic paraplegia 71
Location 5p13.3      Physical location : 32.354.455 - 32.444.844
Synonym name
  • M-phase phosphoprotein homolog
  • likely ortholog of mouse zinc finger protein Zfr
  • Synonym symbol(s) SPG71
    DNA
    TYPE functioning gene
    STRUCTURE 90.42 kb     20 Exon(s)    1 Copie(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC391773 5 similar to Striatin PGBD3P2 5p13.3 piggyBac transposable element derived 3 pseudogene 2 HPRTP2 5p14-p13.3 hypoxanthine phosphoribosyltransferase pseudogene 2 LOC391774 5 similar to hypothetical protein CDH6 5p15.32-p14.2 cadherin 6, type 2, K-cadherin (fetal kidney) RNASE3L 5p15.1 cadherin 6, type 2, K-cadherin (fetal kidney) FLJ11193 5p13.3 hypothetical protein FLJ11193 PDZK3 5p13.2 PDZ domain containing 3 GOLPH3 5p14.1 golgi phosphoprotein 3 (coat-protein) LOC202122 5p13.3 similar to ribosomal protein L27 PIP3AP 5p15.33 phosphatidylinositol-3-phosphate associated protein ZFR 5p13.2 zinc finger RNA binding protein LOC391775 5 similar to Chromosome 1 open reading frame 37 PC4 5p13.3 activated RNA polymerase II transcription cofactor 4 NPR3 5p14-p13 natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) FLJ14054 5p13.3 hypothetical protein FLJ14054 LOC389278 5 similar to 40S ribosomal protein S8 TARS 5p13.3-p13.2 threonyl-tRNA synthetase LOC389279 5 similar to RPE-spondin LOC391776 5 similar to Probable mitochondrial import receptor subunit TOM40 homolog (Translocase of outer membrane 40 kDa subunit homolog) (Haymaker protein) (p38.5) ADAMTS12 5q35 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12 SALPR 5p15.1-p14 G-protein coupled receptor SALPR MATP 5p13.3 membrane associated transporter protein AMACR 5p13.3-p12 alpha-methylacyl-CoA racemase C1QTNF3 5p13-p12 C1q and tumor necrosis factor related protein 3 LOC389280 5 similar to SMA3 protein LOC389281 5 similar to bA110H4.2 (similar to membrane protein) RAI14 5p13.3-p13.2 retinoic acid induced 14 FLJ25439 5p13.3 hypothetical protein FLJ25439 RAD1 5p13.3-p13.2 RAD1 homolog (S. pombe) BRIX 5p13.3 BRIX LOC134218 5p13.3 hypothetical protein LOC134218 AGXT2 5p13 alanine-glyoxylate aminotransferase 2 PRLR 5p14-p13.3 prolactin receptor LOC389282 5 similar to RIKEN cDNA C230086A09 gene FLJ23577 5p13.2 hypothetical protein FLJ23577 IL7R 5p13 interleukin 7 receptor MGC26610 5p13.2 hypothetical protein MGC26610 FLJ34658 5p13.2 hypothetical protein FLJ34658 LOC167127 5p13.2 hypothetical protein LOC167127 DKFZp434H2226 5p13.2 hypothetical protein DKFZp434H2226 SKP2 5p13 S-phase kinase-associated protein 2 (p45) FLJ30596 5p13.2 hypothetical protein FLJ30596
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 4759 - 1074 - 2001 11574164
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainlimbic systemhippocampus   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunemacrophage Homo sapiens
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three central C2H2-type zinc finger motifs
  • HOMOLOGY
    interspecies ortholog to murine Zfr
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • ZFR is a native component of STAU2-containing granules and likely plays its role during early steps of RNA transport and localization
  • is involved in the regulation of growth and cancer development
  • critical role of ZFR in NSCLC tumor growth and metastasis, by targeting the NOTCH1 signaling pathway
  • ZFR represses the interferon response by regulating alternative pre-mRNA splicing
  • regulation of ZFR in macrophage differentiation guards against aberrant interferon responses, suggesting a network of mRNA processing and decay that shapes the transcriptional response to infection
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with RNPS1
  • ZFR, a three zinc finger protein, was identified as an interacting protein of STAU2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPG71
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in non-small-cell lung carcinoma (NSCLC) cells
    tumoral     --over  
    significantly higher in pancreatic tumors than normal pancreas tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    is a promising therapeutic target in metastatic NSCLC
    cancerendocrinepancreas
    knockdown of ZFR suppresses cell proliferation and invasion of human pancreatic cance
    ANIMAL & CELL MODELS