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FLASH GENE
Symbol ZFR contributors: mct - updated : 28-12-2018
HGNC name zinc finger RNA binding protein
HGNC id 17277
Corresponding disease
SPG71 spastic paraplegia 71
Location 5p13.3      Physical location : 32.354.455 - 32.444.844
Synonym name
  • M-phase phosphoprotein homolog
  • likely ortholog of mouse zinc finger protein Zfr
    • Synonym symbol(s) SPG71
    DNA
    TYPE functioning gene
    STRUCTURE 90.42 kb     20 Exon(s)    1 Copie(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 4759 - 1074 - 2001 11574164
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainlimbic systemhippocampus   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunemacrophage Homo sapiens
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three central C2H2-type zinc finger motifs
    • HOMOLOGY
    interspecies ortholog to murine Zfr
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • ZFR is a native component of STAU2-containing granules and likely plays its role during early steps of RNA transport and localization
  • is involved in the regulation of growth and cancer development
  • critical role of ZFR in NSCLC tumor growth and metastasis, by targeting the NOTCH1 signaling pathway
  • ZFR represses the interferon response by regulating alternative pre-mRNA splicing
  • regulation of ZFR in macrophage differentiation guards against aberrant interferon responses, suggesting a network of mRNA processing and decay that shapes the transcriptional response to infection
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with RNPS1
  • ZFR, a three zinc finger protein, was identified as an interacting protein of STAU2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPG71
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in non-small-cell lung carcinoma (NSCLC) cells
    tumoral     --over  
    significantly higher in pancreatic tumors than normal pancreas tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    is a promising therapeutic target in metastatic NSCLC
    cancerendocrinepancreas
    knockdown of ZFR suppresses cell proliferation and invasion of human pancreatic cance
    ANIMAL & CELL MODELS