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FLASH GENE
Symbol ZFR contributors: mct - updated : 28-12-2018
HGNC name zinc finger RNA binding protein
HGNC id 17277
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainlimbic systemhippocampus   Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunemacrophage Homo sapiens
Nervousneuron Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three central C2H2-type zinc finger motifs
  • HOMOLOGY
    interspecies ortholog to murine Zfr
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • ZFR is a native component of STAU2-containing granules and likely plays its role during early steps of RNA transport and localization
  • is involved in the regulation of growth and cancer development
  • critical role of ZFR in NSCLC tumor growth and metastasis, by targeting the NOTCH1 signaling pathway
  • ZFR represses the interferon response by regulating alternative pre-mRNA splicing
  • regulation of ZFR in macrophage differentiation guards against aberrant interferon responses, suggesting a network of mRNA processing and decay that shapes the transcriptional response to infection
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with RNPS1
  • ZFR, a three zinc finger protein, was identified as an interacting protein of STAU2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPG71
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in non-small-cell lung carcinoma (NSCLC) cells
    tumoral     --over  
    significantly higher in pancreatic tumors than normal pancreas tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    is a promising therapeutic target in metastatic NSCLC
    cancerendocrinepancreas
    knockdown of ZFR suppresses cell proliferation and invasion of human pancreatic cance
    ANIMAL & CELL MODELS