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FLASH GENE
Symbol ZFPM1 contributors: mct - updated : 09-09-2015
HGNC name zinc finger protein, multitype 1
HGNC id 19762
Location 16q24.2      Physical location : 88.520.013 - 88.601.573
Synonym name
  • friend of GATA1
  • zinc finger protein ZFPM1
  • zinc finger protein 89A
  • Synonym symbol(s) FOG1, FOG, ZNF408, ZNF89A, ZC2HC11A
    DNA
    TYPE functioning gene
    STRUCTURE 81.56 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    JPH3 16q24.3 junctophilin 3 DKFZp434G0522 16q24.3 hypothetical protein DKFZp434G0522 SLC7A5 16q24.3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 CA5A 16q24.3 carbonic anhydrase VA, mitochondrial BANP 16q24 carbonic anhydrase VA, mitochondrial LOC388306 16 LOC388306 LOC390747 16 similar to proline rich protein ZNF469 16q24 zinc finger protein 469 ZFPM1 16q24.3 zinc finger protein, multitype 1 LOC124245 16q24.3 hypothetical protein BC001584 IL17C 16q24 interleukin 17C CYBA 16q24.2 cytochrome b-245, alpha polypeptide MVD 16q24.2 mevalonate (diphospho) decarboxylase SNAI3 16q24.3 snail homolog 3 (Drosophila) MGC2647 16q24.3 hypothetical zinc finger protein MGC2647 LOC388307 16 similar to LOC348180 protein LOC348180 16q24.3 hypothetical protein LOC348180 KIAA0233 16q24.3 hypothetical protein LOC348180 FLJ40448 16q24.3 hypothetical protein FLJ40448 CDT1 16q24.3 DNA replication factor APRT 16q24.3 adenine phosphoribosyltransferase GALNS 16q24.2 galactosamine (N-acetyl)-6-sulfate sulfatase (Morquio syndrome, mucopolysaccharidosis type IVA) LOC51693 16q24.3 unknown LOC390748 16 similar to putative polyA-binding protein PABPN2/ePABP2 CBFA2T3 16q24.3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 LOC390749 16 LOC390749 LOC197322 16q24.3 hypothetical protein LOC197322 FLJ36701 16q24.3 hypothetical protein FLJ36701 CDH15 16q24.3 cadherin 15, M-cadherin (myotubule) LOC388308 16 similar to Brain-type organic cation transporter FLJ31875 16q24.3 hypothetical protein FLJ31875
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 3241 - 1006 - 2003 12483298
    - - - - - preferentially excluded from the nucleus by unknown mechanisms 2010 19654328
  • also called FOG1S
  • N-terminally truncated version of ZFPM1 is produced from an internal ATG
  • lacks the nucleosome remodeling domain-binding domain, altering the complexes with which it interacts
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
     stomach    
    Endocrinepancreas    
    Lymphoid/Immunelymph node    
    Nervousbrainhindbraincerebellum  
    Reproductivemale systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticerythroid
    Blood/Hematopoieticmegakaryocyte
    Blood/Hematopoieticplatelet
    Lymphoid/ImmuneB cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, fetal
    Text embryonic development, fetal heart, liver, spleen
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • nine zinc fingers motifs
  • conjugated MetalloP
    HOMOLOGY
    interspecies ortholog to murine Fog1
    Homologene
    FAMILY
  • FOG (Friend of GATA) family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • cofactor for GATA1
  • modulator of DNA-binding activity of GATA
  • essential for the proper transcriptional activation and repression of numerous GATA-1 target genes
  • continuous presence of GATA1, ZFPM1, and NuRD is required to maintain lineage fidelity throughout megakaryocyte-erythroid ontogeny
  • recruits two multi-protein complexes, the nucleosome remodeling domain (NuRD) complex and a C-terminal binding protein (CTBP)-containing complex, into association with GATA1 to mediate activation and repression of target genes
  • with components of the CTBP-complex, KDM1A, co-occupy chromatin sites in genes known to be regulated by GATA1
  • ZFPM1, ZFPM2, and CTBP1 and CTBP2 are partners of GATA2, GATA3 proteins in the control of adipocyte proliferation and differentiation
  • is required for the formation of all committed Mk- and E-lineage progenitors, whereas GATA1 was observed to be specifically required for E-lineage commitment
  • CEBPB, CEBPA and ZFPM1 exhibited transcriptional cross-regulation in early myelo-erythroid progenitors making their functional antagonism a potential mechanism for separation of the myeloid and Mk/E lineages
  • its expression is directly or indirectly dependent on the B cell-specific coactivator POU2AF1 and it is modulated during B cell development: expression is observed in early but not in late stages of B cell development
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS development
    text development of erythroid and megakaryocytic lineages
    PATHWAY
    metabolism
    signaling
    a component
  • RBBP4ZFPM1 structure provides insight into the molecular determinants of ZFPM1-dependent association with the NuRD complex and into the links between transcription regulation and nucleosome remodeling
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • essential cofactor of GATA2, interacting through the N finger(s) of GATA
  • under the influence of GATA1, TRIM35 relocates from cytoplasmic granules to the nucleus where it associates with both ZFPM1 and GATA1
  • ZFPM1/NuRD interaction is dispensable for the silencing of human HBG1 and HBG2 expression
  • interacts with transcription factors GATA1 and GATA2 to control erythroid and megakaryocyte (MK) differentiation
  • GATA1-interaction partner, critical for GATA1 function in several contexts by bringing multiple complexes into association with GATA1 to facilitate activation or repression of target genes
  • interact with two repression complexes: a CTBP-containing complex and the NURD repression complex
  • interaction between GATA1 and ZFPM1 is critical for the development of both erythroid and megakaryocytic cell lineages
  • GATA1 and its cofactor ZFPM1 are required for the differentiation of erythrocytes and megakaryocytes
  • exogenous expression of ZFPM1 in mast cells leads to displacement of GATA1 from mast cell-specific genes and causes their downregulation
  • cell & other
    REGULATION
    Other regulated by NURD (NuRD is required for ZFPM1-dependent activation of adult-type globin gene expression but is dispensable for human gamma-globin silencing)
    SUMOylated and phosphorylated in erythroid cells in a differentiation-dependent manner (SUMOylation of ZFPM1 modulates interactions with C-terminal binding protein family members, specifically promoting CTBP1 binding)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    enforced expression of ZFPM1 throughout all hematopoietic lineages led to a reduction in the number of circulating eosinophils, confirming and extending to mammals the known function of ZFPM1 in this lineage
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS