Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

ZFPM1

contributors: mct - updated : 09-09-2015

HGNC name	zinc finger protein, multitype 1
HGNC id	19762

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	16q24.2      Physical location : 88.520.013 - 88.601.573
Synonym name	friend of GATA1
	zinc finger protein ZFPM1
	zinc finger protein 89A
Synonym symbol(s)	FOG1, FOG, ZNF408, ZNF89A, ZC2HC11A

DNA

TYPE	functioning gene
STRUCTURE	81.56 kb     10 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_153813 10 - 3241 NP_722520 - 1006 - 2003 12483298 variant 2 - - - isoform 2 - - preferentially excluded from the nucleus by unknown mechanisms 2010 19654328 also called FOG1S N-terminally truncated version of ZFPM1 is produced from an internal ATG lacks the nucleosome remodeling domain-binding domain, altering the complexes with which it interacts

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver           stomach         Endocrine pancreas         Lymphoid/Immune lymph node         Nervous brain hindbrain cerebellum     Reproductive male system testis

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic erythroid Blood/Hematopoietic megakaryocyte Blood/Hematopoietic platelet Lymphoid/Immune B cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo, fetal

Text	embryonic development, fetal heart, liver, spleen

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

nine zinc fingers motifs

conjugated

MetalloP

HOMOLOGY

interspecies

ortholog to murine Fog1

Homologene

FAMILY

FOG (Friend of GATA) family

CATEGORY

regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,nucleoplasm

basic FUNCTION	cofactor for GATA1
	modulator of DNA-binding activity of GATA
	essential for the proper transcriptional activation and repression of numerous GATA-1 target genes
	continuous presence of GATA1, ZFPM1, and NuRD is required to maintain lineage fidelity throughout megakaryocyte-erythroid ontogeny
	recruits two multi-protein complexes, the nucleosome remodeling domain (NuRD) complex and a C-terminal binding protein (CTBP)-containing complex, into association with GATA1 to mediate activation and repression of target genes
	with components of the CTBP-complex, KDM1A, co-occupy chromatin sites in genes known to be regulated by GATA1
	ZFPM1, ZFPM2, and CTBP1 and CTBP2 are partners of GATA2, GATA3 proteins in the control of adipocyte proliferation and differentiation
	is required for the formation of all committed Mk- and E-lineage progenitors, whereas GATA1 was observed to be specifically required for E-lineage commitment
	CEBPB, CEBPA and ZFPM1 exhibited transcriptional cross-regulation in early myelo-erythroid progenitors making their functional antagonism a potential mechanism for separation of the myeloid and Mk/E lineages
	its expression is directly or indirectly dependent on the B cell-specific coactivator POU2AF1 and it is modulated during B cell development: expression is observed in early but not in late stages of B cell development

CELLULAR PROCESS

cell organization/biogenesis

PHYSIOLOGICAL PROCESS

development

text	development of erythroid and megakaryocytic lineages

PATHWAY

metabolism

signaling

a component

RBBP4·ZFPM1 structure provides insight into the molecular determinants of ZFPM1-dependent association with the NuRD complex and into the links between transcription regulation and nucleosome remodeling

INTERACTION

DNA

RNA

small molecule

protein	essential cofactor of GATA2, interacting through the N finger(s) of GATA
	under the influence of GATA1, TRIM35 relocates from cytoplasmic granules to the nucleus where it associates with both ZFPM1 and GATA1
	ZFPM1/NuRD interaction is dispensable for the silencing of human HBG1 and HBG2 expression
	interacts with transcription factors GATA1 and GATA2 to control erythroid and megakaryocyte (MK) differentiation
	GATA1-interaction partner, critical for GATA1 function in several contexts by bringing multiple complexes into association with GATA1 to facilitate activation or repression of target genes
	interact with two repression complexes: a CTBP-containing complex and the NURD repression complex
	interaction between GATA1 and ZFPM1 is critical for the development of both erythroid and megakaryocytic cell lineages
	GATA1 and its cofactor ZFPM1 are required for the differentiation of erythrocytes and megakaryocytes
	exogenous expression of ZFPM1 in mast cells leads to displacement of GATA1 from mast cell-specific genes and causes their downregulation

cell & other

REGULATION

Other	regulated by NURD (NuRD is required for ZFPM1-dependent activation of adult-type globin gene expression but is dispensable for human gamma-globin silencing)
	SUMOylated and phosphorylated in erythroid cells in a differentiation-dependent manner (SUMOylation of ZFPM1 modulates interactions with C-terminal binding protein family members, specifically promoting CTBP1 binding)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   enforced expression of ZFPM1 throughout all hematopoietic lineages led to a reduction in the number of circulating eosinophils, confirming and extending to mammals the known function of ZFPM1 in this lineage

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS