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FLASH GENE
Symbol ZFPM1 contributors: mct - updated : 09-09-2015
HGNC name zinc finger protein, multitype 1
HGNC id 19762
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 3241 - 1006 - 2003 12483298
- - - - - preferentially excluded from the nucleus by unknown mechanisms 2010 19654328
  • also called FOG1S
  • N-terminally truncated version of ZFPM1 is produced from an internal ATG
  • lacks the nucleosome remodeling domain-binding domain, altering the complexes with which it interacts
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
     stomach    
    Endocrinepancreas    
    Lymphoid/Immunelymph node    
    Nervousbrainhindbraincerebellum  
    Reproductivemale systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticerythroid
    Blood/Hematopoieticmegakaryocyte
    Blood/Hematopoieticplatelet
    Lymphoid/ImmuneB cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, fetal
    Text embryonic development, fetal heart, liver, spleen
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • nine zinc fingers motifs
  • conjugated MetalloP
    HOMOLOGY
    interspecies ortholog to murine Fog1
    Homologene
    FAMILY
  • FOG (Friend of GATA) family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • cofactor for GATA1
  • modulator of DNA-binding activity of GATA
  • essential for the proper transcriptional activation and repression of numerous GATA-1 target genes
  • continuous presence of GATA1, ZFPM1, and NuRD is required to maintain lineage fidelity throughout megakaryocyte-erythroid ontogeny
  • recruits two multi-protein complexes, the nucleosome remodeling domain (NuRD) complex and a C-terminal binding protein (CTBP)-containing complex, into association with GATA1 to mediate activation and repression of target genes
  • with components of the CTBP-complex, KDM1A, co-occupy chromatin sites in genes known to be regulated by GATA1
  • ZFPM1, ZFPM2, and CTBP1 and CTBP2 are partners of GATA2, GATA3 proteins in the control of adipocyte proliferation and differentiation
  • is required for the formation of all committed Mk- and E-lineage progenitors, whereas GATA1 was observed to be specifically required for E-lineage commitment
  • CEBPB, CEBPA and ZFPM1 exhibited transcriptional cross-regulation in early myelo-erythroid progenitors making their functional antagonism a potential mechanism for separation of the myeloid and Mk/E lineages
  • its expression is directly or indirectly dependent on the B cell-specific coactivator POU2AF1 and it is modulated during B cell development: expression is observed in early but not in late stages of B cell development
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS development
    text development of erythroid and megakaryocytic lineages
    PATHWAY
    metabolism
    signaling
    a component
  • RBBP4·ZFPM1 structure provides insight into the molecular determinants of ZFPM1-dependent association with the NuRD complex and into the links between transcription regulation and nucleosome remodeling
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • essential cofactor of GATA2, interacting through the N finger(s) of GATA
  • under the influence of GATA1, TRIM35 relocates from cytoplasmic granules to the nucleus where it associates with both ZFPM1 and GATA1
  • ZFPM1/NuRD interaction is dispensable for the silencing of human HBG1 and HBG2 expression
  • interacts with transcription factors GATA1 and GATA2 to control erythroid and megakaryocyte (MK) differentiation
  • GATA1-interaction partner, critical for GATA1 function in several contexts by bringing multiple complexes into association with GATA1 to facilitate activation or repression of target genes
  • interact with two repression complexes: a CTBP-containing complex and the NURD repression complex
  • interaction between GATA1 and ZFPM1 is critical for the development of both erythroid and megakaryocytic cell lineages
  • GATA1 and its cofactor ZFPM1 are required for the differentiation of erythrocytes and megakaryocytes
  • exogenous expression of ZFPM1 in mast cells leads to displacement of GATA1 from mast cell-specific genes and causes their downregulation
  • cell & other
    REGULATION
    Other regulated by NURD (NuRD is required for ZFPM1-dependent activation of adult-type globin gene expression but is dispensable for human gamma-globin silencing)
    SUMOylated and phosphorylated in erythroid cells in a differentiation-dependent manner (SUMOylation of ZFPM1 modulates interactions with C-terminal binding protein family members, specifically promoting CTBP1 binding)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    enforced expression of ZFPM1 throughout all hematopoietic lineages led to a reduction in the number of circulating eosinophils, confirming and extending to mammals the known function of ZFPM1 in this lineage
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS