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FLASH GENE
Symbol ZFPL1 contributors: mct/npt - updated : 30-05-2008
HGNC name zinc finger protein-like 1
HGNC id 12868
Location 11q13      Physical location : 64.851.693 - 64.855.874
Synonym name
  • zinc-finger protein in MEN1 region
  • zinc finger protein MCG4
    • Synonym symbol(s) H4B, MCG4, D11S750
    DNA
    TYPE functioning gene
    STRUCTURE 4.00 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map see MEN1 MEN1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1400 34.1 310 - Chiu (2008)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrinepancreas   highly
     parathyroid    
    Reproductivemale systemprostate   
     male systemtestis   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two predicted zinc fingers at the N-terminus, the second of which is a likely ring domain
  • an atypical class 2 zinc finger domain
  • a nuclear localization signal (NLS)
  • a C terminal leucine zipper-like motif
    • conjugated PhosphoP
    HOMOLOGY
    Homologene
    FAMILY
  • zinc finger protein family
    • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    text localized to the Golgi apparatus, where it exhibited a high degree of overlap with the cis-Golgi matrix protein GOLGA2
    basic FUNCTION
  • ring finger protein required for cis-Golgi integrity and efficient ER-to-Golgi transport
  • structural component of the Golgi apparatus
  • having an important function in maintaining the integrity of the cis-Golgi and that it does so through interactions with GOLGA2
  • can regulate trafficking between the ER and Golgi apparatus
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • directly interacts with the cis-Golgi matrix protein GOLGA2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS