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FLASH GENE
Symbol ZFPL1 contributors: mct/npt - updated : 30-05-2008
HGNC name zinc finger protein-like 1
HGNC id 12868
DNA
TYPE functioning gene
STRUCTURE 4.00 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map see MEN1 MEN1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1400 34.1 310 - Chiu (2008)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Endocrinepancreas   highly
 parathyroid    
Reproductivemale systemprostate   
 male systemtestis   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two predicted zinc fingers at the N-terminus, the second of which is a likely ring domain
  • an atypical class 2 zinc finger domain
  • a nuclear localization signal (NLS)
  • a C terminal leucine zipper-like motif
  • conjugated PhosphoP
    HOMOLOGY
    Homologene
    FAMILY
  • zinc finger protein family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    text localized to the Golgi apparatus, where it exhibited a high degree of overlap with the cis-Golgi matrix protein GOLGA2
    basic FUNCTION
  • ring finger protein required for cis-Golgi integrity and efficient ER-to-Golgi transport
  • structural component of the Golgi apparatus
  • having an important function in maintaining the integrity of the cis-Golgi and that it does so through interactions with GOLGA2
  • can regulate trafficking between the ER and Golgi apparatus
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • directly interacts with the cis-Golgi matrix protein GOLGA2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS