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FLASH GENE
Symbol YES1 contributors: mct/npt/pgu - updated : 22-05-2019
HGNC name v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
HGNC id 12841
Location 18p11.32      Physical location : 721.593 - 812.327
Synonym name
  • viral oncogene yes-1 homolog 1
  • proto-oncogene tyrosine-protein kinase YES
  • cellular yes-1 protein
  • Yamaguchi sarcoma oncogene
  • Synonym symbol(s) Yes, c-yes, HsT441, P61-YES
    EC.number 2.7.10.2
    DNA
    TYPE functioning gene
    STRUCTURE 90.74 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC388454 18 LOC388454 LOC260334 18p11 HSA18p11 beta-tubulin 4Q pseudogene IL9RP4 18p11.3 interleukin 9 receptor pseudogene 4 USP14 18p ubiquitin specific protease 14 (tRNA-guanine transglycosylase) THOC1 18p11.32 THO complex 1 COLEC12 18pter-p11.3 collectin sub-family member 12 LOC390821 18 LOC390821 CETN1 18p11.32 centrin, EF-hand protein, 1 CLUL1 18p11.32 clusterin-like 1 (retinal) TYMS 18p11.32 thymidylate synthetase HSRTSBETA 18p11.32 rTS beta protein YES1 18p11.31-p11.22 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 ADCYAP1 18p11.31 adenylate cyclase activating polypeptide 1 (pituitary) LOC388456 18 hypothetical gene supported by BC039671 C18orf2 18p11 chromosome 18 open reading frame 2 LOC390822 18 similar to RIKEN cDNA 4921525H23 FLJ23017 HEC 18p11.31 similar to RIKEN cDNA 4921525H23 LOC388457 18 hypothetical gene supported by BC006008 KIAA0650 18p11.31 hypothetical gene supported by BC006008 EMILIN2 18p11.3 elastin microfibril interfacer 2 LPIN2 18p11.31 lipin 2 LOC390823 18 similar to 60S ribosomal protein L10 (QM protein) (Tumor suppressor QM) (Laminin receptor homolog) MYOM1 18p11.32-p11.31 myomesin 1 (skelemin) 185kDa MRCL3 18p11.31 myosin regulatory light chain MRCL3 MRLC2 18p11.31 myosin regulatory light chain MRLC2 LOC204777 18p11.31 similar to Immunoglobulin lambda-like polypeptide 1 precursor (Immunoglobulin-related 14.1 protein) (Immunoglobulin omega polypeptide) (Lambda 5) (CD179b antigen) TGIF 18p11.3 TGFB-induced factor (TALE family homeobox) LOC390824 18 similar to hypothetical protein BC007436 DLGAP1 18p11.3 discs, large (Drosophila) homolog-associated protein 1 MGC11082 18p11.31 hypothetical protein MGC11082
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 4685 - 543 - 1998 9794236
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
     mouthtongue  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    Text highly in embryonic stem (ES) cells
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a SH3 and a SH2 domains (signal transduction)
  • a tyrosine kinase domain
  • HOMOLOGY
    interspecies homolog to Yamaguchi sarcoma viral (v-yes-1) oncogene, 1
    Homologene
    FAMILY
  • protein kinase superfamily
  • Tyr protein kinase family
  • SRC subfamily
  • CATEGORY enzyme , protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    text monopalmitoylated SFK and is biosynthetically transported from the Golgi pool of caveolin to the plasma membrane
    basic FUNCTION
  • monopalmitoylated SFK required for VEGF mitogenic signaling with SRC and FYN, but maintaining distinct properties in the regulation of VEGF-mediated endothelial cell events
  • protein tyrosine kinase related to malignant transformation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • YES1 expression was required in CTNNB1 active cell lines
  • role for YES1 phosphorylation in CTNNB1-driven cancers
  • CRKL signaling was associated with SRC family kinase (SFK) signaling, specifically with YES1 kinase
  • cell & other
  • membrane associated
  • REGULATION
    Other its kinase activity is regulated by leukemia inhibitory factor (LIF) and is down-regulated when cells differentiate
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    and overexpressed in esophageal squamous cell carcinoma
    tumoral     --other  
    nuclear expression found in cancer cells at the early stages of hepatocarcinogenesis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • nucleus-located YES1 may be a useful marker to detect early-stage hepatocellular carcinoma
  • Marker
    Therapy target
    ANIMAL & CELL MODELS