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FLASH GENE
Symbol YES1 contributors: mct/npt/pgu - updated : 22-05-2019
HGNC name v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
HGNC id 12841
DNA
TYPE functioning gene
STRUCTURE 90.74 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
LOC388454 18 LOC388454 LOC260334 18p11 HSA18p11 beta-tubulin 4Q pseudogene IL9RP4 18p11.3 interleukin 9 receptor pseudogene 4 USP14 18p ubiquitin specific protease 14 (tRNA-guanine transglycosylase) THOC1 18p11.32 THO complex 1 COLEC12 18pter-p11.3 collectin sub-family member 12 LOC390821 18 LOC390821 CETN1 18p11.32 centrin, EF-hand protein, 1 CLUL1 18p11.32 clusterin-like 1 (retinal) TYMS 18p11.32 thymidylate synthetase HSRTSBETA 18p11.32 rTS beta protein YES1 18p11.31-p11.22 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 ADCYAP1 18p11.31 adenylate cyclase activating polypeptide 1 (pituitary) LOC388456 18 hypothetical gene supported by BC039671 C18orf2 18p11 chromosome 18 open reading frame 2 LOC390822 18 similar to RIKEN cDNA 4921525H23 FLJ23017 HEC 18p11.31 similar to RIKEN cDNA 4921525H23 LOC388457 18 hypothetical gene supported by BC006008 KIAA0650 18p11.31 hypothetical gene supported by BC006008 EMILIN2 18p11.3 elastin microfibril interfacer 2 LPIN2 18p11.31 lipin 2 LOC390823 18 similar to 60S ribosomal protein L10 (QM protein) (Tumor suppressor QM) (Laminin receptor homolog) MYOM1 18p11.32-p11.31 myomesin 1 (skelemin) 185kDa MRCL3 18p11.31 myosin regulatory light chain MRCL3 MRLC2 18p11.31 myosin regulatory light chain MRLC2 LOC204777 18p11.31 similar to Immunoglobulin lambda-like polypeptide 1 precursor (Immunoglobulin-related 14.1 protein) (Immunoglobulin omega polypeptide) (Lambda 5) (CD179b antigen) TGIF 18p11.3 TGFB-induced factor (TALE family homeobox) LOC390824 18 similar to hypothetical protein BC007436 DLGAP1 18p11.3 discs, large (Drosophila) homolog-associated protein 1 MGC11082 18p11.31 hypothetical protein MGC11082
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 4685 - 543 - 1998 9794236
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
 mouthtongue  highly
Reproductivemale systemtestis  highly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cells
SystemCellPubmedSpeciesStageRna symbol
ReproductiveSertoli cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
Text highly in embryonic stem (ES) cells
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a SH3 and a SH2 domains (signal transduction)
  • a tyrosine kinase domain
  • HOMOLOGY
    interspecies homolog to Yamaguchi sarcoma viral (v-yes-1) oncogene, 1
    Homologene
    FAMILY
  • protein kinase superfamily
  • Tyr protein kinase family
  • SRC subfamily
  • CATEGORY enzyme , protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    text monopalmitoylated SFK and is biosynthetically transported from the Golgi pool of caveolin to the plasma membrane
    basic FUNCTION
  • monopalmitoylated SFK required for VEGF mitogenic signaling with SRC and FYN, but maintaining distinct properties in the regulation of VEGF-mediated endothelial cell events
  • protein tyrosine kinase related to malignant transformation
  • regulates blood-testis barrier (BTB) and apical ectoplasmic specialization (apical ES) integrity by maintaining proper distribution of integral membrane proteins and actin filament organization at these sites
  • upregulated at the Sertoli cell-cell interface at the blood-testis barrier (BTB) at stages VIII-IX of the seminiferous epithelial cycle of spermatogenesis
  • plays an important role in migration and invasion of epithelial ovarian cancer (EOC)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • YES1 and LYN play a role in nuclear translocation of EGFR
  • YES1 expression was required in CTNNB1 active cell lines
  • role for YES1 phosphorylation in CTNNB1-driven cancers
  • CRKL signaling was associated with SRC family kinase (SFK) signaling, specifically with YES1 kinase
  • is a proximal glucose-specific activator of cell division cycle control protein 42 (CDC42) in pancreatic islet beta cells
  • cell & other
  • membrane associated
  • REGULATION
    Other its kinase activity is regulated by leukemia inhibitory factor (LIF) and is down-regulated when cells differentiate
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    and overexpressed in esophageal squamous cell carcinoma
    tumoral     --other  
    nuclear expression found in cancer cells at the early stages of hepatocarcinogenesis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • nucleus-located YES1 may be a useful marker to detect early-stage hepatocellular carcinoma
  • Marker
    Therapy target
    SystemTypeDisorderPubmed
    reproductioncontraception 
    is a likely target of male contraceptive research
    ANIMAL & CELL MODELS