| basic FUNCTION
| may be involved in G-protein associated signal transduction |
|
may itself function as a phosphate sensor |
|
its morphogenetic processes involve intracellular signal transduction (Neumann-Haefelin 2010) |
|
specific role for the phosphate exporter XPR1 in the differentiation of tissue macrophages  |
|
XPR1 played a fundamental role in the maintenance of cellular phosphate balance in the brain |
|
XPR1 promoted phosphorylation and activation of NFKB1 signaling, which is required for XPR1-mediated oncogenic roles |
|
SLC20A2 and XPR1 are transporters with phosphate uptake and efflux functions, respectively |
|
SLC20A2-XPR1 interplay that depends on inositol polyphosphate (IP) such as PP-IPs and controls cellular phosphate homeostasis via the efflux route, and alteration of this interplay likely contributes to primary familial brain calcification (PFBC) |
|
|
