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FLASH GENE
Symbol XPR1 contributors: mct/ - updated : 29-08-2007
HGNC name xenotropic and polytropic retrovirus receptor
HGNC id 12827
Location 1q25.3      Physical location : 180.601.145 - 180.859.413
Synonym name
  • xenotropic and polytropic murine leukemia virus receptor X3
  • protein SYG1 homolog
  • X-receptor
  • Synonym symbol(s) X3, SYG1, FLJ90308, XR
    DNA
    TYPE functioning gene
    STRUCTURE 258.27 kb     15 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - SERPINC1 - D1S212 - XPR1 /D1S308E - D1S3157 - D1S2559 - LAMB2 - qter
    Authors Battini (99)
    Physical map
    DKFZP564J047 1q24.3 hypothetical protein DKFZp564J047 FLJ10244 1q24.3 Ral-A exchange factor RalGPS2 ANGPTL1 1q24.2 angiopoietin-like 1 FAM20B 1q25 family with sequence similarity 20, member B TOR3A 1q24.2-q24.3 torsin family 3, member A ABL2 1q24-q25 v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene) SOAT1 1q25 sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1 FLJ32940 1q24.3 hypothetical protein FLJ32940 NPHS2 1q25-q31 nephrosis 2, idiopathic, steroid-resistant (podocin) LOC126860 1q24.3 similar to centaurin, gamma 2 TDRD5 1q24.2 tudor domain containing 5 MGC16664 1q25.1 hypothetical protein MGC16664 LOC163590 1q25.1 AF464140 IFRG15 1q25.1 IFRG15 protein LAP1B 1q24.2 lamina-associated polypeptide 1B CAP350 1p36.13-q41 lamina-associated polypeptide 1B QSCN6 1q24 quiescin Q6 FLJ23867 1q25.1 hypothetical protein FLJ23867 LHX4 1q24.1-q24.3 LIM homeobox 4 LOC388717 1 LOC388717 ACBD6 1q25.1 acyl-Coenzyme A binding domain containing 6 XPR1 1q25 xenotropic and polytropic retrovirus receptor KIAA1614 1q25.1 KIAA1614 protein LOC391142 1 hypothetical gene supported by AJ249778; NM_001531 STX6 1p36 syntaxin 6 MR1 1q25.3 major histocompatibility complex, class I-related IER5 1q25.1 immediate early response 5 LOC284646 1q25.1 hypothetical gene supported by BC039493 CACNA1E 1q25-q31 calcium channel, voltage-dependent, alpha 1E subunit LOC127665 1q25.2 similar to zinc finger protein 135 (clone pHZ-17); zinc finger protein 61 LOC388718 1 similar to Protein translation factor SUI1 homolog (Sui1iso1) GLUL 1q31 glutamate-ammonia ligase (glutamine synthase) HE9 1q25.2 putative membrane protein HE9 LOC388719 1 hypothetical gene supported by AF508909 LOC127671 1q25.2 similar to CE9 protein RGSL2 1q25.2 regulator of G-protein signalling like 2 RGSL1  regulator of G-protein signalling like 1 RNASEL 1q25 ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) RGS16 1q25-q31 regulator of G-protein signalling 16 RGS8 1q25-q31 regulator of G-protein signalling 8 NPL 1q25 N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) DHX9 1q25 DEAH (Asp-Glu-Ala-His) box polypeptide 9
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 8305 73.8 631 - -
    15 - 8500 81.4 696 - -
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     intestinesmall intestine  moderately
     liver   highly
    Endocrineadrenal gland   highly
     parathyroid   highly
    Hearing/Equilibriumearinnercochlea moderately
    Nervousbrain    
     nervecranial nerve  moderately
    Reproductivefemale systemovary  moderately
     male systemtestis  highly
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • eight or nine potential membrane-spanning regions
  • seven potential N-glycosylation sites
  • seven dileucines that may stimulate endocytosis via clathrin-coated pits
  • lack of the highly conserved cytoplasmic PDZ-binding motif
  • HOMOLOGY
    interspecies homolog to rattus Xpr1 (96 pc)
    homolog to murine Xpr1 (95.4 pc)
    Homologene
    FAMILY
  • SYG1 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may be involved in G-protein associated signal transduction
  • may itself function as a phosphate sensor
  • its morphogenetic processes involve intracellular signal transduction (Neumann-Haefelin 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    G protein-coupled
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • could be shown to interact with NPHS1 (Neumann-Haefelin 2010)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS