basic FUNCTION
| may be involved in G-protein associated signal transduction |
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may itself function as a phosphate sensor |
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its morphogenetic processes involve intracellular signal transduction (Neumann-Haefelin 2010) |
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specific role for the phosphate exporter XPR1 in the differentiation of tissue macrophages |
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XPR1 played a fundamental role in the maintenance of cellular phosphate balance in the brain |
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XPR1 promoted phosphorylation and activation of NFKB1 signaling, which is required for XPR1-mediated oncogenic roles |
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SLC20A2 and XPR1 are transporters with phosphate uptake and efflux functions, respectively |
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SLC20A2-XPR1 interplay that depends on inositol polyphosphate (IP) such as PP-IPs and controls cellular phosphate homeostasis via the efflux route, and alteration of this interplay likely contributes to primary familial brain calcification (PFBC) |
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