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FLASH GENE
Symbol XPR1 contributors: mct/ - updated : 01-09-2020
HGNC name xenotropic and polytropic retrovirus receptor
HGNC id 12827
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 8305 73.8 631 - 2020 32019887
15 - 8500 81.4 696 - 2020 32019887
11 - 3835 - 503 - 2020 32019887
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 intestinesmall intestine  moderately
 liver   highly
Endocrineadrenal gland   highly
 parathyroid   highly
Hearing/Equilibriumearinnercochlea moderately
Nervousbrainhindbraincerebellum highly Homo sapiens
 brainbasal nucleistriatum highly Homo sapiens
Reproductivefemale systemovary  moderately
 male systemtestis  highly
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • eight or nine potential membrane-spanning regions
  • seven potential N-glycosylation sites
  • seven dileucines that may stimulate endocytosis via clathrin-coated pits
  • lack of the highly conserved cytoplasmic PDZ-binding motif
  • HOMOLOGY
    interspecies homolog to rattus Xpr1 (96 pc)
    homolog to murine Xpr1 (95.4 pc)
    Homologene
    FAMILY
  • SYG1 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • may be involved in G-protein associated signal transduction
  • may itself function as a phosphate sensor
  • its morphogenetic processes involve intracellular signal transduction (Neumann-Haefelin 2010)
  • specific role for the phosphate exporter XPR1 in the differentiation of tissue macrophages
  • XPR1 played a fundamental role in the maintenance of cellular phosphate balance in the brain
  • XPR1 promoted phosphorylation and activation of NFKB1 signaling, which is required for XPR1-mediated oncogenic roles
  • SLC20A2 and XPR1 are transporters with phosphate uptake and efflux functions, respectively
  • SLC20A2-XPR1 interplay that depends on inositol polyphosphate (IP) such as PP-IPs and controls cellular phosphate homeostasis via the efflux route, and alteration of this interplay likely contributes to primary familial brain calcification (PFBC)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    G protein-coupled
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • could be shown to interact with NPHS1 (Neumann-Haefelin 2010)
  • expression of retro-viral receptor, XPR1, is regulated by TNFSF11-TNFRSF11A signaling
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) IBGC6
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • might be a potential prognostic marker in tongue squamous cell carcinoma (TSCC)
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestive 
    therapeutic target in tongue squamous cell carcinoma (TSCC) tissues
    ANIMAL & CELL MODELS
  • deletion of Xpr1 gene in renal proximal tubules in mice leads to hypophosphatemic rickets and Fanconi syndrome