SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,cytosolic
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| intracellular,nucleus,nucleoplasm
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| intracellular,nucleus,chromatin/chromosome,kinetochore
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| intracellular,nucleus,nucleolus
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| intracellular,nuclear envelope,pore
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text
| located at centrosomes through its N-terminal CRIME domain interacting with RanGTP |
basic FUNCTION
| essential mediator of the leucine-rich NES-dependent nuclear export of proteins in a process requiring the GTP bound form of RanGTPase |
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mediates nuclear export of numerous unrelated cargoes, which may carry a short leucine-rich nuclear export signal or export signatures that include folded domains |
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implicated in the centrosomal association of NPM1 |
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maintaining centrosome integrity, disrupted by hepatitis B viral protein X |
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mediating nuclear export of HDAC7A independently of HDAC7A phosphorylation and its association with SFN |
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with ILKAP, are pivotal modulators of ILK subcellular distribution and activity in the keratinocytes |
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might interact with pericentrin and regulate the localization and function of pericentrin at centrosomes |
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critical involvement of the XPO1 transport receptor in dendritic cells maturation, most likely by enabling efficient nucleo-cytoplasmic translocation of specific mRNAs |
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exhibits large overall structural dynamics, in line with other transport receptors such as KPNB1, XPOT, and CSE1L |
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karyopherin that mediates nuclear export of proteins and ribonucleoproteins bearing a leucine-rich nuclear export signal (NES) |
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controls the composition of nucleoplasmic pre-snoRNA complexes to licence them for nucleolar transport |
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plays a key role in normal cell functioning, mediating the nucleo-cytoplasmic transport of cargo proteins |
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XPO1, BARD1 and AURKA promote the targeting and function of BRCA1 at centrosomes |
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IPO7 and XPO1 link MYC and TP53 to regulation of ribosomal biogenesis |
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is essential for nuclear depletion of numerous structurally and functionally unrelated protein and ribonucleoprotein cargoes |
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adopt a toroidal structure in several functional transport complexes and was thought to maintain this conformation throughout the entire nucleocytoplasmic transport cycle |
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is involved in the nuclear translocation of proteins and certain RNAs from the nucleus to the cytoplasm and is thus crucial for the correct localisation of cellular components |
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mediates nuclear export of hundreds of proteins through recognition of their nuclear export signals (NESs), which are highly variable in sequence and structure |
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nuclear pores are essential for spatial genome organization and gene regulation and XPO1 (exportin 1/CRM1) is the key nuclear export protein |
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binds nuclear export signals (NESs), and mediates active transport of NES-bearing proteins from the nucleus to the cytoplasm |
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regulatory role of XPO1 in juxta-nuclear microtubule-dependent adenovirus transport |
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nuclear transport receptors KPNB1 and XPO1 play essential roles in localising the RANBP2-SUMO-RANGAP1 complex away from, or at kinetochores, respectively |
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XPO1 regulates the nuclear localization of many proteins including tumor suppressor proteins |