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Symbol XPO1 contributors: mct/pgu - updated : 04-02-2019
HGNC name exportin 1 (CRM1 homolog, yeast)
HGNC id 12825
Location 2p15      Physical location : 61.705.069 - 61.765.418
Synonym name
  • exportin-1 required for chromosome region maintenance
  • chromosome region maintenance 1 protein homolog
  • CRM1, yeast, homolog
  • Synonym symbol(s) CRM1, DKFZp686B1823, Exp1
    TYPE functioning gene
    STRUCTURE 60.35 kb     25 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    25 - 4830 123.2 1071 - 2000 1108016
    Type ubiquitous
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
    Reproductivefemale systemuteruscervix highly
     male systemtestis   
    Urinarybladder   highly
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    cell lineage
    cell lines
    at STAGE
  • a N-terminal importin beta domain
  • a coiled-coil domain
  • 20 HEAT repeats (HEAT repeat generally contains two antiparallel helices A and B, each lining the convex and concave side of the protein)
  • C-terminal helix is a major determinant restricting the conformational flexibility and thus shifting the population more toward the extended conformation
  • secondary structure
  • in the free state can adopt a compact, ring-like structure, and an extended, superhelical structure
  • exportin family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nuclear envelope,pore
    text located at centrosomes through its N-terminal CRIME domain interacting with RanGTP
    basic FUNCTION
  • essential mediator of the leucine-rich NES-dependent nuclear export of proteins in a process requiring the GTP bound form of RanGTPase
  • mediates nuclear export of numerous unrelated cargoes, which may carry a short leucine-rich nuclear export signal or export signatures that include folded domains
  • implicated in the centrosomal association of NPM1
  • maintaining centrosome integrity, disrupted by hepatitis B viral protein X
  • mediating nuclear export of HDAC7A independently of HDAC7A phosphorylation and its association with SFN
  • with ILKAP, are pivotal modulators of ILK subcellular distribution and activity in the keratinocytes
  • might interact with pericentrin and regulate the localization and function of pericentrin at centrosomes
  • critical involvement of the XPO1 transport receptor in dendritic cells maturation, most likely by enabling efficient nucleo-cytoplasmic translocation of specific mRNAs
  • exhibits large overall structural dynamics, in line with other transport receptors such as KPNB1, XPOT, and CSE1L
  • karyopherin that mediates nuclear export of proteins and ribonucleoproteins bearing a leucine-rich nuclear export signal (NES)
  • controls the composition of nucleoplasmic pre-snoRNA complexes to licence them for nucleolar transport
  • plays a key role in normal cell functioning, mediating the nucleo-cytoplasmic transport of cargo proteins
  • XPO1, BARD1 and AURKA promote the targeting and function of BRCA1 at centrosomes
  • IPO7 and XPO1 link MYC and TP53 to regulation of ribosomal biogenesis
  • is essential for nuclear depletion of numerous structurally and functionally unrelated protein and ribonucleoprotein cargoes
  • adopt a toroidal structure in several functional transport complexes and was thought to maintain this conformation throughout the entire nucleocytoplasmic transport cycle
  • is involved in the nuclear translocation of proteins and certain RNAs from the nucleus to the cytoplasm and is thus crucial for the correct localisation of cellular components
  • mediates nuclear export of hundreds of proteins through recognition of their nuclear export signals (NESs), which are highly variable in sequence and structure
  • nuclear pores are essential for spatial genome organization and gene regulation and XPO1 (exportin 1/CRM1) is the key nuclear export protein
  • binds nuclear export signals (NESs), and mediates active transport of NES-bearing proteins from the nucleus to the cytoplasm
  • regulatory role of XPO1 in juxta-nuclear microtubule-dependent adenovirus transport
  • nuclear transport receptors KPNB1 and XPO1 play essential roles in localising the RANBP2-SUMO-RANGAP1 complex away from, or at kinetochores, respectively
  • XPO1 regulates the nuclear localization of many proteins including tumor suppressor proteins
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text needed for translocation across the nuclear pore complex
    a component
  • constituent of nuclear pore complex and nucleoplasm
    small molecule
  • associating in a subcomplex with NUP214 and NUP88
  • forming a complex with EIF5A
  • exporting STAT1, SMURF1 from the nucleus
  • linked to CHC1 (RCC1) by RANBP3
  • STRADA facilitates nuclear export of STK11 by serving as an adaptor between STK11 and exportins XPO1 and XPO7
  • XPO1-mediated nuclear export may be required for the proper execution of ubiquitin-proteasome-dependent degradation of SERTAD2
  • binds SNUPN in a bipartite manner by means of an amino-terminal LR-NES (leucine-rich nuclear export signal) and its nucleotide-binding domain
  • NUP98 functions as a novel shuttling cofactor for XPO1-mediated nuclear export in conjunction with RANBP3
  • interaction with AVEN (regulation of the ATM-activator protein AVEN by XPO1-dependent nuclear export)
  • RANBP3 acts as a XPO1 cofactor, enhancing NES export by stabilizing the export complex in the nucleus
  • competitive binding mechanism between SKP1 and exportin 1 (XPO1) controls the localization of a subset of F-box proteins
  • binds to specific amino acid motifs termed NESs (nuclear export sequences)
  • binds to undimerized BRCA1 and is displaced by BARD1
  • interacting with BACH1 (BACH1 is predominantly exported to the cytoplasm in a XPO1-dependent manner)
  • KPNB1 having functions at kinetochores exerted via RANBP2 and opposed by XPO1
  • XPO1 and EIF4E seem to play an important role in the nucleocytoplasmic export of human NOS2 mRNA
  • AKT3 is likely a regulator of mitochondrial dynamics in the vasculature via regulation of XPO1-dependent nuclear export
  • a binding interaction between the exportin XPO1 and the unstructured carboxylic tail of TPR, suggesting that this interaction is vital to the functions of XPO1
  • mediates nuclear export of hundreds of proteins through recognition of their nuclear export signals (NESs), which are highly variable in sequence and structure
  • RANGAP1 is actively transported between the nuclear and cytoplasmic compartments, and the cytoplasmic and nuclear pore complex (NPC) localization of RANGAP1 is dependent on XPO1-mediated nuclear export
  • highly selective targeting of NUP98-fusion proteins to HOX cluster regions via prebound XPO1 induces the formation of higher order chromatin structures that causes aberrant HOX gene regulation
  • XPO1 is a novel binding partner of nucleoprotein (NP) that stimulates NP-mediated nuclear export via the CRM1-dependent pathway
  • nuclear exporting of TNS4 is a XPO1-dependent process
  • cell & other
    inhibited by inhibited by HIV1 viral protein Rev
    Other cell-cycle regulated gene
    its transcription is inhibited by DNA damage and the mechanism of inhibition involves TP53 interfering with NFY function
    XPO1-mediated export is regulated by RANBP3, a Ran-interacting nuclear protein
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   translocation   protein chimeric
    tumoral     --over  
    in cervical cancer and critical for cancer cell survival and proliferation
    tumoral     --over  
    overexpressed in cancer
    tumoral somatic mutation      
    in primary mediastinal diffuse large B cell lymphoma and classical Hodgkin lymphoma
    tumoral     --over  
    in oesophageal cancer and is required for the proliferation and survival of oesophageal cancer cells
    Susceptibility to autism spectrum disorders (ASD)
    Variant & Polymorphism SNP
  • rs6735330 was associated with were associated with ASD
  • Candidate gene
    Therapy target
    promising candidate as both biomarker and potential anticancer therapeutic target
    XPO1 inhibition could be a novel promising agent used in combination with conventional chemotherapeutics and AR-targeted therapy for the better treatment of PCa, especially castrate-resistant prostate cancer (CRPC)
    therapeutic targeting of XPO1 has emerged as a novel cancer treatment strategy