basic FUNCTION
| binding photoproduct (damage recognition in the process of nucleotide excision repair) |
|
monitoring DNA binding and unwinding and exercizing an architectural function in DNA repair |
|
transcription-coupled repair (TCR) of oxidative lesions |
|
critical role of XPA as a scaffold might explain why XP-A patients or XPA-deficient cells exhibit the most severe phenotypes among seven complementation groups of NER-defective XP |
|
possible key role of XPA orientation in conjunction with RPA1 binding to undamaged strand for the positioning of the NER (nucleotide excision repair) preincision complex |
|
proper orientation of XPA and RPA1 in the stage of preincision was achieved in the absence of ERCC3 and XPG |
|
central but somewhat elusive role in nucleotide excision repair |
|
its phosphorylation enhanced the chromatin retention of XPA, the interaction with its binding partners following DNA damage |
|
essential protein in the nucleotide excision repair (NER) pathway, in charge of recruiting the ERCC1-XPF endonuclease complex to the DNA damage site |