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FLASH GENE
Symbol WNT3A contributors: shn/npt/pgu - updated : 01-04-2016
HGNC name wingless-type MMTV integration site family, member 3A
HGNC id 15983
Location 1q42.13      Physical location : 228.194.751 - 228.248.961
Synonym name protein Wnt-3a
Synonym symbol(s) MGC119418, MGC119419, MGC119420
DNA
TYPE anonymous DNA segment
SPECIAL FEATURE component of a cluster
text clustered with WNT14
STRUCTURE 59.69 kb     4 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - D1S479 - D1S1644 - WNT3A - D1S1617 - D1S2847 - qter
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 2988 - 352 - 2002 11836627
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale system   moderately
 male systemprostate  lowly
Respiratorylung   lowly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text lowly in placenta, fetal skin and epidermal stem cells
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an amino-terminal secretory signal peptide followed by a short domain of low sequence conservation
  • then by a large conserved domain that includes 22 cysteine residues
  • HOMOLOGY
    interspecies homolog to Wnt3a, Mus musculus
    ortholog to Wnt3a, Rattus norvegicus
    ortholog to wnt3a, Danio rerio
    ortholog to WNT3A, Pan troglodytes
    Homologene
    FAMILY
  • WNT gene family
  • CATEGORY protooncogene , signaling
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    text secreted and associates with the extracellular matrix
    basic FUNCTION
  • may be a signaling molecule which affects the development of discrete regions of tissues
  • inhibits chondrogenesis by stabilizing cell-cell adhesion and that it causes dedifferentiation of chondrocytes by activating of beta-catenin-Tcf/Lef transcriptional complex and the c-Jun/AP-1 pathway
  • stimulates the formation of PIP5K5K1A, PIP54K1B, PIP5K1C through frizzled and dishevelled, the latter of which directly interacted with and activated PIP5KI
  • acted synergistically with Rspo1 to activate Wnt/beta-catenin signaling
  • triggers the interaction of LRP6 with caveolin and promotes recruitment of Axin to LRP6 phosphorylated by glycogen synthase kinase-3beta
  • regulates survival, expansion, and maintenance of neural progenitors derived from human embryonic stem cells
  • regulates the development of cardiac neural crest cells by modulating expression of CRIP2 in rhombomere 6
  • stimulates the formation of phosphatidylinositol 4,5-bisphosphates [PtdIns (4,5)P2] through frizzled
  • acts in parallel to induce the caveolin-dependent internalization of LRP6, as well as the phosphorylation of LRP6 and the recruitment of Axin to LRP6 on the cell surface membrane
  • with DKK1, shunt LRP6 to distinct internalization pathways in order to activate and inhibit the beta-catenin signaling, respectively
  • induces canonical and non-canonical Wnt signaling in HUVECs, and stimulates their proliferation and migration
  • altered platelet shape change and inhibited the activation of the small GTPase RhoA
  • promotes the formation of a myofibroblast-like phenotype in cultured fibroblasts, in part, by upregulating TGFB1 signaling through SMAD2 in a CTNNB-dependent mechanism
  • plays an important role in melanocyte homeostasis
  • can induce epithelial-mesenchymal transition (EMT), migration, and proliferation of human lens epithelial (HLE) cells
  • modulates chondrogenesis via canonical and non-canonical Wnt pathways in mesenchymal stem cells (MSCs)
  • stimulates maturation of impaired neutrophils developed from severe congenital neutropenia patient-derived pluripotent stem cells
  • WNT3A and FZD3 signalings play important roles in regulating the proliferation and differentiation of neural crest (NC) cells and various developmental stages of melanocyte precursors
  • activator of the canonical Wnt signaling pathway
  • may play an important role in the pathogenesis of Hirschsprung disease (HSCR)
  • WNT8A and WNT3A cooperate in the axial stem cell niche to promote mammalian body axis extension
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • WNT3A/CTNNB signaling plays important roles during embryonic development, morphogenesis, cell proliferation, differentiation and migration
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • frizzled homolog 1, FZD1 (Gazit et al, 1999)
  • FHL2 controls the osteogenic differentiation of mesenchymal stromal cells (MSC), bone formation and bone mass through modulation of WNT molecules, WNT10B, WNT3A, WNT5A
  • HES5 is a key mediator of the WNT3A proneurogenic effect occurring independently of the classical WNT/CTNNB1 signaling cascade thus further deciphering crosstalk mechanisms of WNT and NOTCH1 signaling pathways regulating cell fate of human neural stem/progenitor cell (hNPC)
  • AXIN1 and NFE2L2 physically associated in a protein complex that was regulated by WNT3A, involving the central region of AXIN1 and the Neh4/Neh5 domains of NFE2L2
  • interaction between LEF1 and WWTR1 is crucial for the osteoblastogenic activity of WNT3A and LEF1 and WWTR1 contribute to the cooperative effect of WNT3A and BMP2 on osteoblast differentiation through association with RUNX2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    blood  
    activation of the WNT3A/CTNNB1 pathway may offer a novel therapy for SCNP1 with ELANE mutation
    neurosensorialvisuallens
    may be a valuable therapeutic target for the prevention and treatment of Posterior capsular opacification (PCO)
    ANIMAL & CELL MODELS