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FLASH GENE

Symbol

WNT3A

contributors: shn/npt/pgu - updated : 01-04-2015

HGNC name	wingless-type MMTV integration site family, member 3A
HGNC id	15983

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1q42.13      Physical location : 228.194.751 - 228.248.961
Synonym name	protein Wnt-3a
Synonym symbol(s)	MGC119418, MGC119419, MGC119420

DNA

TYPE	anonymous DNA segment
SPECIAL FEATURE	component of a cluster
text	clustered with WNT14
STRUCTURE	59.69 kb     4 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map	cen - D1S479 - D1S1644 - WNT3A - D1S1617 - D1S2847 - qter

Physical map

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_033131 4 - 2988 NP_149122 - 352 - 2002 11836627

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system       moderately   male system prostate     lowly Respiratory lung       lowly

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text	lowly in placenta, fetal skin and epidermal stem cells

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an amino-terminal secretory signal peptide followed by a short domain of low sequence conservation
	then by a large conserved domain that includes 22 cysteine residues

HOMOLOGY

interspecies	homolog to Wnt3a, Mus musculus
	ortholog to Wnt3a, Rattus norvegicus
	ortholog to wnt3a, Danio rerio
	ortholog to WNT3A, Pan troglodytes

Homologene

FAMILY

WNT gene family

CATEGORY

protooncogene , signaling

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,lumen
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,organelle,endosome
text	secreted and associates with the extracellular matrix

basic FUNCTION	may be a signaling molecule which affects the development of discrete regions of tissues
	inhibits chondrogenesis by stabilizing cell-cell adhesion and that it causes dedifferentiation of chondrocytes by activating of beta-catenin-Tcf/Lef transcriptional complex and the c-Jun/AP-1 pathway
	stimulates the formation of PIP5K5K1A, PIP54K1B, PIP5K1C through frizzled and dishevelled, the latter of which directly interacted with and activated PIP5KI
	acted synergistically with Rspo1 to activate Wnt/beta-catenin signaling
	triggers the interaction of LRP6 with caveolin and promotes recruitment of Axin to LRP6 phosphorylated by glycogen synthase kinase-3beta
	regulates survival, expansion, and maintenance of neural progenitors derived from human embryonic stem cells
	regulates the development of cardiac neural crest cells by modulating expression of CRIP2 in rhombomere 6
	stimulates the formation of phosphatidylinositol 4,5-bisphosphates [PtdIns (4,5)P2] through frizzled
	acts in parallel to induce the caveolin-dependent internalization of LRP6, as well as the phosphorylation of LRP6 and the recruitment of Axin to LRP6 on the cell surface membrane
	with DKK1, shunt LRP6 to distinct internalization pathways in order to activate and inhibit the beta-catenin signaling, respectively
	induces canonical and non-canonical Wnt signaling in HUVECs, and stimulates their proliferation and migration
	altered platelet shape change and inhibited the activation of the small GTPase RhoA
	promotes the formation of a myofibroblast-like phenotype in cultured fibroblasts, in part, by upregulating TGFB1 signaling through SMAD2 in a CTNNB-dependent mechanism
	plays an important role in melanocyte homeostasis
	can induce epithelial-mesenchymal transition (EMT), migration, and proliferation of human lens epithelial (HLE) cells
	modulates chondrogenesis via canonical and non-canonical Wnt pathways in mesenchymal stem cells (MSCs)
	stimulates maturation of impaired neutrophils developed from severe congenital neutropenia patient-derived pluripotent stem cells
	WNT3A and FZD3 signalings play important roles in regulating the proliferation and differentiation of neural crest (NC) cells and various developmental stages of melanocyte precursors
	activator of the canonical Wnt signaling pathway
	may play an important role in the pathogenesis of Hirschsprung disease (HSCR)
	WNT8A and WNT3A cooperate in the axial stem cell niche to promote mammalian body axis extension

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

WNT3A/CTNNB signaling plays important roles during embryonic development, morphogenesis, cell proliferation, differentiation and migration

INTERACTION

DNA

RNA

small molecule

protein	frizzled homolog 1, FZD1 (Gazit et al, 1999)
	FHL2 controls the osteogenic differentiation of mesenchymal stromal cells (MSC), bone formation and bone mass through modulation of WNT molecules, WNT10B, WNT3A, WNT5A
	HES5 is a key mediator of the WNT3A proneurogenic effect occurring independently of the classical WNT/CTNNB1 signaling cascade thus further deciphering crosstalk mechanisms of WNT and NOTCH1 signaling pathways regulating cell fate of human neural stem/progenitor cell (hNPC)
	AXIN1 and NFE2L2 physically associated in a protein complex that was regulated by WNT3A, involving the central region of AXIN1 and the Neh4/Neh5 domains of NFE2L2

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed blood     activation of the WNT3A/CTNNB1 pathway may offer a novel therapy for SCNP1 with ELANE mutation neurosensorial visual lens may be a valuable therapeutic target for the prevention and treatment of Posterior capsular opacification (PCO)

ANIMAL & CELL MODELS