SUBCELLULAR LOCALIZATION
| extracellular
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| intracellular
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| intracellular,cytoplasm,organelle,lumen
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,organelle,endosome
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text
| secreted and associates with the extracellular matrix |
basic FUNCTION
| may be a signaling molecule which affects the development of discrete regions of tissues |
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inhibits chondrogenesis by stabilizing cell-cell adhesion and that it causes dedifferentiation of chondrocytes by activating of beta-catenin-Tcf/Lef transcriptional complex and the c-Jun/AP-1 pathway |
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stimulates the formation of PIP5K5K1A, PIP54K1B, PIP5K1C through frizzled and dishevelled, the latter of which directly interacted with and activated PIP5KI |
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acted synergistically with Rspo1 to activate Wnt/beta-catenin signaling |
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triggers the interaction of LRP6 with caveolin and promotes recruitment of Axin to LRP6 phosphorylated by glycogen synthase kinase-3beta  |
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regulates survival, expansion, and maintenance of neural progenitors derived from human embryonic stem cells  |
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regulates the development of cardiac neural crest cells by modulating expression of CRIP2 in rhombomere 6  |
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stimulates the formation of phosphatidylinositol 4,5-bisphosphates [PtdIns (4,5)P2] through frizzled  |
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acts in parallel to induce the caveolin-dependent internalization of LRP6, as well as the phosphorylation of LRP6 and the recruitment of Axin to LRP6 on the cell surface membrane  |
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with DKK1, shunt LRP6 to distinct internalization pathways in order to activate and inhibit the beta-catenin signaling, respectively  |
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induces canonical and non-canonical Wnt signaling in HUVECs, and stimulates their proliferation and migration  |
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altered platelet shape change and inhibited the activation of the small GTPase RhoA  |
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promotes the formation of a myofibroblast-like phenotype in cultured fibroblasts, in part, by upregulating TGFB1 signaling through SMAD2 in a CTNNB-dependent mechanism  |
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plays an important role in melanocyte homeostasis  |
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can induce epithelial-mesenchymal transition (EMT), migration, and proliferation of human lens epithelial (HLE) cells  |
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modulates chondrogenesis via canonical and non-canonical Wnt pathways in mesenchymal stem cells (MSCs)  |
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stimulates maturation of impaired neutrophils developed from severe congenital neutropenia patient-derived pluripotent stem cells  |
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WNT3A and FZD3 signalings play important roles in regulating the proliferation and differentiation of neural crest (NC) cells and various developmental stages of melanocyte precursors  |
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activator of the canonical Wnt signaling pathway  |
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may play an important role in the pathogenesis of Hirschsprung disease (HSCR)  |
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WNT8A and WNT3A cooperate in the axial stem cell niche to promote mammalian body axis extension  |