SUBCELLULAR LOCALIZATION
| extracellular
|
| intracellular
|
| intracellular,cytoplasm,organelle,lumen
|
| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,organelle,endoplasmic reticulum
|
| intracellular,cytoplasm,organelle,Golgi
|
| intracellular,cytoplasm,organelle,endosome
|
text
| secreted and associates with the extracellular matrix |
basic FUNCTION
| may be a signaling molecule which affects the development of discrete regions of tissues |
|
inhibits chondrogenesis by stabilizing cell-cell adhesion and that it causes dedifferentiation of chondrocytes by activating of beta-catenin-Tcf/Lef transcriptional complex and the c-Jun/AP-1 pathway |
|
stimulates the formation of PIP5K5K1A, PIP54K1B, PIP5K1C through frizzled and dishevelled, the latter of which directly interacted with and activated PIP5KI |
|
acted synergistically with Rspo1 to activate Wnt/beta-catenin signaling |
|
triggers the interaction of LRP6 with caveolin and promotes recruitment of Axin to LRP6 phosphorylated by glycogen synthase kinase-3beta |
|
regulates survival, expansion, and maintenance of neural progenitors derived from human embryonic stem cells |
|
regulates the development of cardiac neural crest cells by modulating expression of CRIP2 in rhombomere 6 |
|
stimulates the formation of phosphatidylinositol 4,5-bisphosphates [PtdIns (4,5)P2] through frizzled |
|
acts in parallel to induce the caveolin-dependent internalization of LRP6, as well as the phosphorylation of LRP6 and the recruitment of Axin to LRP6 on the cell surface membrane |
|
with DKK1, shunt LRP6 to distinct internalization pathways in order to activate and inhibit the beta-catenin signaling, respectively |
|
induces canonical and non-canonical Wnt signaling in HUVECs, and stimulates their proliferation and migration |
|
altered platelet shape change and inhibited the activation of the small GTPase RhoA |
|
promotes the formation of a myofibroblast-like phenotype in cultured fibroblasts, in part, by upregulating TGFB1 signaling through SMAD2 in a CTNNB-dependent mechanism |
|
plays an important role in melanocyte homeostasis |
|
can induce epithelial-mesenchymal transition (EMT), migration, and proliferation of human lens epithelial (HLE) cells |
|
modulates chondrogenesis via canonical and non-canonical Wnt pathways in mesenchymal stem cells (MSCs) |
|
stimulates maturation of impaired neutrophils developed from severe congenital neutropenia patient-derived pluripotent stem cells |
|
WNT3A and FZD3 signalings play important roles in regulating the proliferation and differentiation of neural crest (NC) cells and various developmental stages of melanocyte precursors |
|
activator of the canonical Wnt signaling pathway |
|
may play an important role in the pathogenesis of Hirschsprung disease (HSCR) |
|
WNT8A and WNT3A cooperate in the axial stem cell niche to promote mammalian body axis extension |