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FLASH GENE
Symbol WNT3 contributors: shn/mct - updated : 06-11-2018
HGNC name wingless-type MMTV integration site family, member 3
HGNC id 12782
Corresponding disease
TETAMS1 tetra-amelia syndrome 1
Location 17q21.32      Physical location : 44.841.686 - 44.896.082
Synonym name WNT-3 proto-oncogene protein
Synonym symbol(s) INT4, MGC131950, MGC138321, MGC138323, TETAMS
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem, component of a cluster
text clustered with WNT15
STRUCTURE 56.25 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Map cen - D17S920 - D17S791- WNT3 - D17S1834 - D17S931 - qter
Physical map
LOC339193 17q21.31 similar to dead end homolog 1; dead end protein FLJ25168 17q21.31 hypothetical protein FLJ25168 CRHR1 17q12-q22 corticotropin releasing hormone receptor 1 IMP5 17q21.31 intramembrane protease 5 MAPT 17q21.11 microtubule-associated protein tau DKFZP727C091 LOC284054 17q21.32 similar to C-jun-amino-terminal kinase interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1) LOC124981 17q21.32 similar to dead end homolog 1; dead end protein LOC388392 17 similar to FALZ protein LOC201173 17q21.32 similar to KIAA0563 protein LOC51326 17q21.32 ARF protein NSF 17q21-q22 N-ethylmaleimide-sensitive factor WNT3 17q21.31 wingless-type MMTV integration site family, member 3 LOC388393 17 LOC388393 WNT9B 17q21 wingless-type MMTV integration site family, member 9B GOSR2 17q21 golgi SNAP receptor complex member 2 LOC388394 17 similar to RIKEN cDNA 2410012A13 LOC388395 17 similar to Hypothetical protein KIAA0563 LOC388396 17 similar to KIAA0563 protein LOC388397 17 LOC388397 CDC27 17q21.3 cell division cycle 27 MYL4 17q21.2 myosin, light polypeptide 4, alkali; atrial, embryonic ITGB3 17q21.31 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) FLJ40342 17q21.32 hypothetical protein FLJ40342 NPEPPS 17q21.2-q21.32 aminopeptidase puromycin sensitive KPNB1 17q21.32 karyopherin (importin) beta 1 ProSAPiP2 17q21.32 ProSAPiP2 protein TBX21 17q21.3 T-box 21 OSBPL7 17q21.2 oxysterol binding protein-like 7 MRPL10 17q21.32 mitochondrial ribosomal protein L10 MGC16309 17q21.32 hypothetical gene MGC16309 Ses2 17q21.32 secernin 2 SP6 17q21.3-q22 Sp6 transcription factor LOC388398 17 LOC388398 SP2 17q21.3-q22 Sp2 transcription factor PNPO 17q21.32 pyridoxine-5'-phosphate oxidase
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1506 - 355 - 2017 29269485
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestivestomach    
Endocrineparathyroid    
Nervousbraindiencephalonthalamus  
 brainhindbraincerebellum  
 brainhindbrainpons  
 braindiencephalonhypothalamus  
Reproductivemale systemtestis   
cell lineage expressed by motoneurons and adult hippocampal stem/progenitor cells
cell lines human breast cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text in developing nervous system
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal signal peptide
  • two N-linked glycosylation sites
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to Drosophila wingless (wg) segment polarity gene
    ortholog to Wnt3, Mus musculus
    ortholog to Wnt3, Rattus norvegicus
    ortholog to wnt3, Danio rerio
    ortholog to WNT3, Pan troglodytes
    intraspecies homolog to WNT3A
    Homologene
    FAMILY WNT gene family
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • modulating cell fate and cell behavior during vertebrate development
  • required for the primary axis formation, for urogenital, limb, and craniofacial development
  • may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway
  • involved in tumorigenesis
  • acts as a retrograde signal that controls terminal arborization of muscle afferents (Krylova et al, 2002)
  • acts as an intrinsic regulator of hippocampal neurogenesis by modulating the generation of newborn neurons in the adult dentate gyrus (Zhou et al, 2004)
  • acts as an axon guidance molecule and plays a role in retinotectal mapping along the medial-lateral axis (Schmitt et al, 2006)
  • functions as a modulator of postsynaptic differentiation at the vertebrate peripheral neuromuscular synapses by collaborating with agrin (Henriquez et al, 2008)
  • both the levels of WNT3 protein and the number of WNT3-secreting astrocytes influence the impairment of adult neurogenesis during aging
  • is a biomarker capable of predicting the definitive endoderm differentiation potential of hESCs
  • novel role for WNT3 as a regulator of neurogenesis and repressor of neural tumors
  • WNT3 and WNT5B are critical factors secreted from Transforming growth factor-induced mesenchymal cancer cells for instigating the epithelial cancer cell invasion along with the induction of secondary EMT phenotype
  • WNT3 and membrane-associated CTNNB1 regulate trophectoderm lineage differentiation in human blastocysts
  • YAP1 maintains hESC pluripotency by preventing WNT3 expression in response to Activin, thereby blocking a direct route to embryonic cardiac mesoderm formation
  • is an important modulator of axon regeneration, and is a key intrinsic regulator of axon growth ability of the nervous system
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS development
    text
  • neurogenesis
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • frizzled homolog 1, FZD1 (Gazit et al, 1999)
  • KDM6A and KDM6B contribute to the activation of WNT3 and DKK1 at different differentiation stages when WNT3 and DKK1 are required for mesendoderm and definitive endoderm differentiation, respectively
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) TETAMS1
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast and rectal cancer
    tumoral     --over  
    during the progression of non-small cell lung cancer (NSCLC), WNT3 overexpression could be associated with the development of more aggressive tumors
    Susceptibility to non-syndromic cleft lip with or without cleft palate (NSCL/P)
    Variant & Polymorphism SNP
  • rs3809857 and rs9890413 polymorphisms of WNT3 appeared to be associated with NSCL/P
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Wnt3-/- mice develop a normal egg cylinder but do not form a primitive streak, mesoderm or node (Liu et al, 1999)