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FLASH GENE
Symbol WNT3 contributors: shn/mct - updated : 06-11-2018
HGNC name wingless-type MMTV integration site family, member 3
HGNC id 12782
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal signal peptide
  • two N-linked glycosylation sites
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to Drosophila wingless (wg) segment polarity gene
    ortholog to Wnt3, Mus musculus
    ortholog to Wnt3, Rattus norvegicus
    ortholog to wnt3, Danio rerio
    ortholog to WNT3, Pan troglodytes
    intraspecies homolog to WNT3A
    Homologene
    FAMILY WNT gene family
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • modulating cell fate and cell behavior during vertebrate development
  • required for the primary axis formation, for urogenital, limb, and craniofacial development
  • may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway
  • involved in tumorigenesis
  • acts as a retrograde signal that controls terminal arborization of muscle afferents (Krylova et al, 2002)
  • acts as an intrinsic regulator of hippocampal neurogenesis by modulating the generation of newborn neurons in the adult dentate gyrus (Zhou et al, 2004)
  • acts as an axon guidance molecule and plays a role in retinotectal mapping along the medial-lateral axis (Schmitt et al, 2006)
  • functions as a modulator of postsynaptic differentiation at the vertebrate peripheral neuromuscular synapses by collaborating with agrin (Henriquez et al, 2008)
  • both the levels of WNT3 protein and the number of WNT3-secreting astrocytes influence the impairment of adult neurogenesis during aging
  • is a biomarker capable of predicting the definitive endoderm differentiation potential of hESCs
  • novel role for WNT3 as a regulator of neurogenesis and repressor of neural tumors
  • WNT3 and WNT5B are critical factors secreted from Transforming growth factor-induced mesenchymal cancer cells for instigating the epithelial cancer cell invasion along with the induction of secondary EMT phenotype
  • WNT3 and membrane-associated CTNNB1 regulate trophectoderm lineage differentiation in human blastocysts
  • YAP1 maintains hESC pluripotency by preventing WNT3 expression in response to Activin, thereby blocking a direct route to embryonic cardiac mesoderm formation
  • is an important modulator of axon regeneration, and is a key intrinsic regulator of axon growth ability of the nervous system
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS development
    text
  • neurogenesis
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • frizzled homolog 1, FZD1 (Gazit et al, 1999)
  • KDM6A and KDM6B contribute to the activation of WNT3 and DKK1 at different differentiation stages when WNT3 and DKK1 are required for mesendoderm and definitive endoderm differentiation, respectively
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) TETAMS1
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast and rectal cancer
    tumoral     --over  
    during the progression of non-small cell lung cancer (NSCLC), WNT3 overexpression could be associated with the development of more aggressive tumors
    Susceptibility to non-syndromic cleft lip with or without cleft palate (NSCL/P)
    Variant & Polymorphism SNP
  • rs3809857 and rs9890413 polymorphisms of WNT3 appeared to be associated with NSCL/P
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Wnt3-/- mice develop a normal egg cylinder but do not form a primitive streak, mesoderm or node (Liu et al, 1999)