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FLASH GENE

Symbol

WNT10B

contributors: mlc/npt - updated : 25-08-2016

HGNC name	wingless-type MMTV integration site family, member 10B
HGNC id	12775

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	SHFM6 split hand and foot malformation 6 STHAG8 tooth agenesis, selective, 8
Location	12q13.12      Physical location : 49.359.123 - 49.365.641
Synonym name	WNT-10B protein
Synonym symbol(s)	WNT12, WNT-12

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster, head to head, opposite orientation
text	clustered with WNT1, in a head-to-head manner with an interval of less than 7kb
STRUCTURE	6.42 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003394 5 - 2370 NP_003385 40 389 - 2015 25995040

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Homo sapiens Digestive mouth tooth       Homo sapiens Skin/Tegument skin         Homo sapiens Adult   skin         Homo sapiens Fetal

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone       Muscular striatum cardiac     Homo sapiens Muscular striatum skeletal     Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Digestive epithelial cell Homo sapiens Muscular myocyte Homo sapiens Skeleton osteoclast Skin/Tegument keratinocyte Homo sapiens Adult Skin/Tegument keratinocyte Homo sapiens Fetal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

growth/childhood

Text	brain highly

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

cysteine rich domains

conjugated

GlycoP

HOMOLOGY

interspecies	homolog to Drosophila wingless (Wg) segment polarity gene
	homolog to murine mammary tumor virus integration site oncogene
	homolog to C.elegans k10b4.6
	homolog to murine Wnt10b

intraspecies

homolog to WNT10A

Homologene

FAMILY

WNT family

CATEGORY

protooncogene , signaling

SUBCELLULAR LOCALIZATION	extracellular
text	associated with the extracellular matrix

basic FUNCTION	modulating cell fate and cell behavior during vertebrate development
	molecular switch governing adipognesis
	ligand for mrmbers of the frizzled family of seven transmembrane receptors
	may be implicated in self renewal of stem cells as well as in carcinogenesis through activation of the WNT - beta-catenin pathway
	may play a role in the negative regulation of adipocyte differentiation
	acting as a key signaling molecule promoting osteoblastogenesis and inhibiting adipogenesis
	primarily increases bone mass by stimulating osteoblastogenesis (Bennett 2007)
	established regulator of mesenchymal stem cell (MSC) fate that inhibits adipogenesis and stimulates osteoblastogenesis, thereby impacting bone mass
	WNT6, WNT10A and WNT10B inhibit adipogenesis and stimulate osteoblastogenesis through a CTNNB1-dependent mechanism
	canonical Wnts, specifically WNT10B, play important roles in the maintenance of dermal papilla (DP) cells and trichogenesis
	signaling protein regulating skin development and homeostasis
	promotes epidermal keratinocyte transformation through induced EGF pathway
	causes nuclear transport and binding of RAC1 and CTNNB1 in human corneal endothelial cells, leading to the activation of CCND1 expression and proliferation

CELLULAR PROCESS

cell communication

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

signal transduction

cell-to-cell signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	ligand for members of the frizzled family of seven transmembrane receptors
	FHL2 controls the osteogenic differentiation of mesenchymal stromal cells (MSC), bone formation and bone mass through modulation of WNT molecules, WNT10B, WNT3A, WNT5A
	WNT10B/DKK1 can modulate hair follicle size during hair regeneration

cell & other

REGULATION

activated by

TGFB1 (TGB1 stimulates WNT10B production in osteoclasts, which may enhance restoration of the bone lost during the resorptive phase of bone turnover)

ASSOCIATED DISORDERS

corresponding disease(s)

SHFM6 , STHAG8

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in breast carcinoma, esophageal and cervical cancer constitutional       loss of function results in age-dependent loss of bone mass and progressive reduction of mesenchymal progenitor cells

Susceptibility

to obesity (minor gene)

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

in Wnt10b(-/-) mice, changes in mineralizing variables and osteoblast perimeter in femoral distal metaphyses were not observed; however, bone formation rate is reduced because of decreased total bone volume and trabecular number (Bennett 2007)