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FLASH GENE
Symbol WNT10B contributors: mlc/npt - updated : 25-08-2016
HGNC name wingless-type MMTV integration site family, member 10B
HGNC id 12775
Corresponding disease
SHFM6 split hand and foot malformation 6
STHAG8 tooth agenesis, selective, 8
Location 12q13.12      Physical location : 49.359.123 - 49.365.641
Synonym name WNT-10B protein
Synonym symbol(s) WNT12, WNT-12
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster, head to head, opposite orientation
text clustered with WNT1, in a head-to-head manner with an interval of less than 7kb
STRUCTURE 6.42 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
ANP32D 12p11.1 acidic (leucine-rich) nuclear phosphoprotein 32 family, member D MGC35033 12q13.12 hypothetical protein MGC35033 LOC341568 12q13.12 similar to seven transmembrane helix receptor LOC390313 12 similar to seven transmembrane helix receptor LALBA 12q13.1 lactalbumin, alpha- LOC121270 12q13.12 similar to olfactory receptor MOR122-1 FLJ20436 12q13.12 hypothetical protein FLJ20436 CCNT1 12q13.1 cyclin T1 LOC255411 12q13.12 hypothetical LOC255411 ADCY6 12q12-q13 adenylate cyclase 6 LOC390314 12 similar to Protein C20orf27 CACNB3 12q13 calcium channel, voltage-dependent, beta 3 subunit DDX23 12q13.12 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 RHO6 12q12-q13 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 NYD-SP28 12q13.12 NYD-SP28 protein FKBP11 12q13.2 FK506 binding protein 11, 19 kDa ARF3 12q13.1 ADP-ribosylation factor 3 WNT10B 12q13.1 wingless-type MMTV integration site family, member 10B WNT1 12q13 wingless-type MMTV integration site family, member 1 DDN 12q13.12 dendrin PRKAG1 12q12-q14 protein kinase, AMP-activated, gamma 1 non-catalytic subunit MLL2 12q12-q13 myeloid/lymphoid or mixed-lineage leukemia 2 RHEBL1 12q13.12 Ras homolog enriched in brain like 1 DHH 12q12-q13.1 desert hedgehog homolog (Drosophila) LIMR 12q13.12 lipocalin-interacting membrane receptor K-ALPHA-1 12q12-q14.3 lipocalin-interacting membrane receptor TUBA3 12q12-12q14.3 lipocalin-interacting membrane receptor TUBA6 12q12-q14 tubulin alpha 6 PRPH 12q12-q13 peripherin TROAP 12p11.1 trophinin associated protein (tastin) LOC338761 12q13.12 similar to C1q-related factor precursor FLJ13236 12q13.12 hypothetical protein FLJ13236 SPATS2 12q13.12 spermatogenesis associated, serine-rich 2
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 2370 40 389 - 2015 25995040
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly Homo sapiens
Digestivemouthtooth    Homo sapiens
Skin/Tegumentskin     Homo sapiensAdult
 skin     Homo sapiensFetal
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
Muscularstriatumcardiac   Homo sapiens
Muscularstriatumskeletal  
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Digestiveepithelial cell Homo sapiens
Muscularmyocyte Homo sapiens
Skeletonosteoclast
Skin/Tegumentkeratinocyte Homo sapiensAdult
Skin/Tegumentkeratinocyte Homo sapiensFetal
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period growth/childhood
Text brain highly
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • cysteine rich domains
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to Drosophila wingless (Wg) segment polarity gene
    homolog to murine mammary tumor virus integration site oncogene
    homolog to C.elegans k10b4.6
    homolog to murine Wnt10b
    intraspecies homolog to WNT10A
    Homologene
    FAMILY
  • WNT family
  • CATEGORY protooncogene , signaling
    SUBCELLULAR LOCALIZATION extracellular
    text associated with the extracellular matrix
    basic FUNCTION
  • modulating cell fate and cell behavior during vertebrate development
  • molecular switch governing adipognesis
  • ligand for mrmbers of the frizzled family of seven transmembrane receptors
  • may be implicated in self renewal of stem cells as well as in carcinogenesis through activation of the WNT - beta-catenin pathway
  • may play a role in the negative regulation of adipocyte differentiation
  • acting as a key signaling molecule promoting osteoblastogenesis and inhibiting adipogenesis
  • primarily increases bone mass by stimulating osteoblastogenesis (Bennett 2007)
  • established regulator of mesenchymal stem cell (MSC) fate that inhibits adipogenesis and stimulates osteoblastogenesis, thereby impacting bone mass
  • WNT6, WNT10A and WNT10B inhibit adipogenesis and stimulate osteoblastogenesis through a CTNNB1-dependent mechanism
  • canonical Wnts, specifically WNT10B, play important roles in the maintenance of dermal papilla (DP) cells and trichogenesis
  • signaling protein regulating skin development and homeostasis
  • promotes epidermal keratinocyte transformation through induced EGF pathway
  • causes nuclear transport and binding of RAC1 and CTNNB1 in human corneal endothelial cells, leading to the activation of CCND1 expression and proliferation
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling signal transduction
    cell-to-cell signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand for members of the frizzled family of seven transmembrane receptors
  • FHL2 controls the osteogenic differentiation of mesenchymal stromal cells (MSC), bone formation and bone mass through modulation of WNT molecules, WNT10B, WNT3A, WNT5A
  • WNT10B/DKK1 can modulate hair follicle size during hair regeneration
  • cell & other
    REGULATION
    activated by TGFB1 (TGB1 stimulates WNT10B production in osteoclasts, which may enhance restoration of the bone lost during the resorptive phase of bone turnover)
    ASSOCIATED DISORDERS
    corresponding disease(s) SHFM6 , STHAG8
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast carcinoma, esophageal and cervical cancer
    constitutional       loss of function
    results in age-dependent loss of bone mass and progressive reduction of mesenchymal progenitor cells
    Susceptibility to obesity (minor gene)
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • in Wnt10b(-/-) mice, changes in mineralizing variables and osteoblast perimeter in femoral distal metaphyses were not observed; however, bone formation rate is reduced because of decreased total bone volume and trabecular number (Bennett 2007)