Symbol
| WNT10B
| contributors: mlc/npt - updated : 25-08-2016
|
HGNC name
| wingless-type MMTV integration site family, member 10B
|
HGNC id
| 12775
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
| --over
|  
|
in breast carcinoma, esophageal and cervical cancer | constitutional
|  
|  
|  
| loss of function
|
results in age-dependent loss of bone mass and progressive reduction of mesenchymal progenitor cells | |
Susceptibility
|
to obesity (minor gene) |
Variant & Polymorphism
|
| |
Candidate gene
Marker
Therapy target
| | | |
| in Wnt10b(-/-) mice, changes in mineralizing variables and osteoblast perimeter in femoral distal metaphyses were not observed; however, bone formation rate is reduced because of decreased total bone volume and trabecular number (Bennett 2007) |