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FLASH GENE
Symbol WNT10B contributors: mlc/npt - updated : 25-08-2016
HGNC name wingless-type MMTV integration site family, member 10B
HGNC id 12775
ASSOCIATED DISORDERS
corresponding disease(s) SHFM6 , STHAG8
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in breast carcinoma, esophageal and cervical cancer
constitutional       loss of function
results in age-dependent loss of bone mass and progressive reduction of mesenchymal progenitor cells
Susceptibility to obesity (minor gene)
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • in Wnt10b(-/-) mice, changes in mineralizing variables and osteoblast perimeter in femoral distal metaphyses were not observed; however, bone formation rate is reduced because of decreased total bone volume and trabecular number (Bennett 2007)