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FLASH GENE
Symbol WDR1 contributors: np/ - updated : 23-08-2007
HGNC name WD repeat domain 1
HGNC id 12754
Location 4p16.1      Physical location : 10.075.963 - 10.118.573
Synonym name
  • actin interacting protein 1
  • WD repeat-containing protein 1
  • Synonym symbol(s) NORI-1, AIP1
    DNA
    TYPE functioning gene
    STRUCTURE 42.61 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map pter - D4S412 - HD - D4S2925 - D4S3007 - D4S394 - D4S2923 - WDR1 - D4S1599 - D4S403 - D4S1601 - cen
    Physical map
    LOC391624 4 similar to ubiquitin-specific protease 17-like protein LOC391625 4 similar to ubiquitin-specific protease 17-like protein LOC391626 4 similar to ubiquitin-specific protease 17-like protein LOC391627 4 similar to ubiquitin-specific protease 17-like protein LOC391628 4 similar to ubiquitin-specific protease 17-like protein LOC389200 4 similar to hypothetical protein LOC169270 LOC285479 4p16.1 hypothetical gene supported by NM_030930; AY007125 LOC391629 4 similar to seven transmembrane helix receptor LOC391630 4 similar to seven transmembrane helix receptor LOC391631 4 similar to Alkaline sphingomyelinase LOC285544 4p16.1 similar to mannosyltransferase LOC391632 4 similar to putative taste receptor HTR2 LOC389201 4 LOC389201 DRD5 4p16.1 dopamine receptor D5 SLC2A9 4p16-p15.3 solute carrier family 2 (facilitated glucose transporter), member 9 WDR1 4p16.1 WD repeat domain 1 RAF1P1 4p16.1 v-raf-1 murine leukemia viral oncogene homolog 1 pseudogene 1 KIAA1729 4p16.1 KIAA1729 protein LOC391633 4 similar to 14.5 kDa translational inhibitor protein (p14.5) (UK114 antigen homolog) MIST  mast cell immunoreceptor signal transducer
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 splicing 3160 66.2 606 - 1999 10036186
    12 splicing 2740 - 466 - 1999 10036186
    lacking the last two WD domains
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
    Endocrinethyroid   highly
    Lymphoid/Immunespleen   highly
     thymus   highly
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    14 WD40 repeats, which make up two propellers (the N-terminal propeller and the C-terminal propeller, structural motifs that mediate protein
    protein interactions)
    HOMOLOGY
    interspecies ortholog to chicken gene (upregulated in the acoustically chicken basilar papilla)
    ortholog to murine Wdr1
    homolog to Drosophila CG10724
    homolog to C.elegans K08F9.2
    Homologene
    FAMILY
  • WD repeat gene family
  • AIP1 family of WD-repeat proteins
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION inducing disassembly of actin filaments in conjunction with ADF/cofilin family proteins
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling sensory transduction/hearing
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to actin
  • interaction between the C-terminal WD40 propeller of WDR1 and the CARD domain of SFRS2IP
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS