basic FUNCTION
| inducing disassembly of actin filaments in conjunction with ADF/cofilin family proteins |
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plays an important role in directional cell migration by restricting the stimulus-induced membrane protrusion to one direction via promoting cofilin activity  |
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WDR1 enhances CFL1-mediated actin disassembly in the apical region of precluster cells to promote remodeling of adherens junctions (AJs) and thus intercellular movement, but also robust actin polymerization promotes AJ general adhesion and integrity during the remodeling process  |
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could be an actin dynamics promoter that specifically regulates AJ function during epithelial morphogenesis  |
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role of WDR1 in regulating the structure and remodeling of intestinal epithelial junctions and early steps of epithelial morphogenesis  |
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regulates CFL1-mediated actin depolymerization, which is required for normal neutrophil function  |
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plays likely an important role in suppressing platelet activity, where it alters the actin cytoskeleton dynamics  |
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highly conserved actin-binding protein across all eukaryotes and is involved in numerous actin-based processes by accelerating Cofilin severing actin filament  |
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importance of WDR1 and actin regulation in the activation of the inflammasome, and in human autoinflammation  |
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WDR1-regulated actin dynamics is required for outflow tract and right ventricle development  |
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role for WDR1 in adaptive immunity, highlighting WDR1 as a central regulator of actin turnover during formation of the B-cell and T-cell immunologic synapses  |
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WDR1 is essential for the localization of CFL1 to the platelet membrane skeleton  |
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CFL1 and WDR1 are evolutionally conserved proteins that cooperatively sever actin filaments  |