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FLASH GENE
Symbol WARS2 contributors: mct - updated : 30-05-2007
HGNC name tryptophanyl tRNA synthetase 2 (mitochondrial)
HGNC id 12730
Location 1p13.3-p13.1      Physical location : 119.573.840 - 119.683.295
Synonym name
  • tryptophan-tRNA ligase
  • tryptophanyl-tRNA synthetase
  • Synonym symbol(s) WARS, TRPRS
    EC.number 6.1.1.2
    DNA
    TYPE anonymous DNA segment
    STRUCTURE 109.00 kb     6 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure IFN-gamma-sensitive promoter
    MAPPING cloned Y linked   status provisional
    Map pter - D1S252 - D1S453 - WARS2 - D1S514 - cen
    Authors Martinez-Dominguez (98)
    Physical map
    LOC391072 1 similar to protease (prosome, macropain) 26S subunit, ATPase 1 LOC343492 1p12 similar to Vigilin (High density lipoprotein-binding protein) (HDL-binding protein) TBX15 1p13 T-box 15 WARS2 1p13.3-p13.1 tryptophanyl tRNA synthetase 2 (mitochondrial) LOC343495 1p11.2 similar to 60S ribosomal protein L6 (TAX-responsive enhancer element binding protein 107) (TAXREB107) (Neoplasm-related protein C140) HAO2 1p13.3-p13.2 hydroxyacid oxidase 2 (long chain) HSD3B2 1p13.1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 LOC391073 1 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) LOC391074 1 similar to 3 BETA-HYDROXYSTEROID DEHYDROGENASE/DELTA 5-->4-ISOMERASE (3BETA-HSD) LOC391075 1 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) LOC391076 1 similar to 3 BETA-HYDROXYSTEROID DEHYDROGENASE/DELTA 5-->4-ISOMERASE (3BETA-HSD) LOC391077 1 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) HSD3B1 1p13.1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 LOC391078 1 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) LOC391079 1 similar to 3 BETA-HYDROXYSTEROID DEHYDROGENASE/DELTA 5-->4-ISOMERASE (3BETA-HSD) LOC128102 1p11.2 3-beta-hydroxysteroid dehydrogenase, tissue-type heart LOC391080 1 similar to glyceraldehyde 3-phosphate dehydrogenase LOC391081 1 similar to 3 BETA-HYDROXYSTEROID DEHYDROGENASE/DELTA 5-->4-ISOMERASE (3BETA-HSD) MGC45731 1p11.2 hypothetical protein MGC45731 PHGDH 1p12 phosphoglycerate dehydrogenase HMGCS2 1p12 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) REG4 1q12-q21 regenerating islet-derived family, member 4 LOC343505 1p11.2 similar to dJ1182A14.5.1 (novel gene (isoform 1)) LOC391082 1 similar to Profilin I ADAM30 1p12-p11 a disintegrin and metalloproteinase domain 30
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2806 - 360 - Oh
    - - 2835 - 220 - Oh
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
    Reproductivefemale systemuteruscervix highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    signal peptide for mitochondrial import
    HOMOLOGY
    interspecies homolog to bacterial tryptophanyl tRNA synthetase
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION unknown
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated by gamma-interferon (IFN-gamma), an anti-proliferative cytokine known to stimulate the expression of other anti-angiogenic factors
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS