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FLASH GENE
Symbol VTN contributors: mct - updated : 30-11-2016
HGNC name vitronectin (serum spreading factor, somatomedin B, complement S-protein)
HGNC id 12724
Location 17q11.2      Physical location : 26.694.300 - 26.697.373
Synonym name
  • serum spreading factor
  • S-protein
  • epibolin
  • somatomedin B
  • Synonym symbol(s) VN, V75, VNT
    DNA
    TYPE functioning gene
    STRUCTURE 3.01 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC390782 17 similar to 60S ribosomal protein L10 (QM protein) (Tumor suppressor QM) (Laminin receptor homolog) NLK 17q11.2 nemo-like kinase PYY2 17q11.1-q11.2 peptide YY, 2 (seminalplasmin) PPY2 17q11.1-q11.2 pancreatic polypeptide 2 LOC339274 17q11.2 similar to Hypothetical protein KIAA0563 FLJ40504 17q11.2 hypothetical protein FLJ40504 MAC30 17q11.2 hypothetical protein FLJ40504 LOC90410 17q11.2 intraflagellar transport protein IFT20 TNFAIP1 17q11 tumor necrosis factor, alpha-induced protein 1 (endothelial) PDIP38 MGC45714 17q11.2 hypothetical protein MGC45714 VTN 17q11.2 vitronectin (serum spreading factor, somatomedin B, complement S-protein) SARM1 17q11 sterile alpha and TIR motif containing 1 MGC9564 17q11.2 similar to RIKEN cDNA 1110002C08 gene LOC388363 17 similar to 40S ribosomal protein S7 (S8) SLC13A2 17p11.1-q11.1 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 FOXN1 17q11.2 forkhead box N1 UNC119 17q11.2 unc-119 homolog (C. elegans) PIGS 17p13.2 phosphatidylinositol glycan, class S ALDOC 17q11.2 aldolase C, fructose-bisphosphate SPAG5 17q11.1 sperm associated antigen 5 FLJ25006 17q11.2 hypothetical protein FLJ25006 KIAA0100 17q11.2 KIAA0100 gene product SDF2 17q11.2 stromal cell-derived factor 2 SUPT6H 17q11.2 suppressor of Ty 6 homolog (S. cerevisiae) MGC39650 17q11.2 hypothetical protein MGC39650 RAB34 17q11.1 RAB34, member RAS oncogene family RPL23A 17q11 ribosomal protein L23a LOC116238 17q11.2 hypothetical protein BC014072 NEK8 17q11.1 NIMA (never in mitosis gene a)- related kinase 8 TRAF4 17q11-q12 TNF receptor-associated factor 4 FLJ10700 17q11.2 hypothetical protein FLJ10700
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1678 - 478 - 2015 26101327
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousspinal cord     Homo sapiensFetal
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelial    
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Visualcone photoreceptor
    Visualganglion cell
    cell lineage
    cell lines
    fluid/secretion plasma
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a somatomedin B (SMB) domain, which comprises the N-terminal 44 AAs of VTN interacting with the flexible joint region of SERPINE1
  • two hemopexin-like domains
  • a RGD motif, integrin-binding sequence, regulating TGFB1-induced alveolar epithelial cell apoptosis
  • a heparin binding domain involved in the oligomerization process and such oligomerization reinforces the activity of VTN in cell adhesion and spreading
  • conjugated GlycoP
    mono polymer monomer , dimer
    isoforms Precursor precursor of 65 and 10kDa chains
    HOMOLOGY
    Homologene
    FAMILY pexin family
    CATEGORY immunity/defense , regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text secreted
    basic FUNCTION
  • inhibitor of the cytolytic action of the terminal complement cascade growth hormone-dependent serum factor with protease-inhibiting activity
  • modulating SHH response in central nervous system
  • VTN and SERPINE1 are proteins that interact in the circulatory system and pericellular region to regulate fibrinolysis, cell adhesion, and migration
  • beneficial effect of VTN on oligodendrocytic differentiation of human embryonic stem cells (hESCs)
  • is a multi-functional protein found predominantly as a monomer in blood and as an oligomer in the extracellular matrix
  • is a glycoprotein found in normal serum and pathological extracellular matrix
  • inhibits neutrophil apoptosis through activation of integrin-associated signaling pathways
  • plays a previously unrecognized role in regulating endothelial permeability via conformational- and integrin-dependent effects on CDH5 trafficking
  • is involved in the whole process of atherosclerosis
  • may be involved in the pathogenesis of early-onset severe preeclampsia (EOSP), by inducing an imbalance between coagulation and fibrinolysis
  • importance of VTN and its interaction with the PLAUR in tumor growth
  • inhibits efferocytosis through interactions with apoptotic cells as well as with macrophages
  • adhesion to VTN allows likely for the uncoupling of FBN1 fibril formation from downstream signaling events by reducing ITGB1/ITGA5 integrin activation and FBN1 fibril extension
  • importance of VTN in the regulation of angiogenesis induced by VEGFA
  • plays a significant role in the malignant growth of tumor
  • Dental Bud Stem Cells (DBSCs) differentiation toward osteoblastic lineage was enhanced when cells were grown on fibronectin (FN1), vitronectin (VTN), and osteopontin (SPP1)
  • promotes the progress of the initial differentiation stage of cerebellar granule cell precursors (CGCPs)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • several proteinase inhibitors of the serpin family inhibiting PAI1 activation mediating the anchorage of PAT1 to fibrin filaments and as such modulating fibrinotysis
  • PLAUR is a non-integrin vitronectin (VTN) cell adhesion receptor linked to the plasma membrane by a glycolipid anchor
  • proapoptotic function of SERPINE1 is mediated through vitronectin (VTN) inhibition
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in sera from patients with Joint hypermobility syndrome (JHS)
    Susceptibility to vascular disease (chronic or acute myocardial infarctus , or deep venous thrombosis)
    Variant & Polymorphism SNP
  • rs2227721 was associated with susceptibility to vascular disease
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerbone 
    may serve as a potential therapeutic target in osteosarcoma
    cancerdigestiveliver
    inhibition of VTN could potentially be applied for the treatment of hepatocellular carcinoma
    cancerreproductiveovary
    could represent a target for the development of anti-adhesive strategies to impede ovarian cancer dissemination
    ANIMAL & CELL MODELS