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FLASH GENE
Symbol VTN contributors: mct - updated : 30-11-2016
HGNC name vitronectin (serum spreading factor, somatomedin B, complement S-protein)
HGNC id 12724
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a somatomedin B (SMB) domain, which comprises the N-terminal 44 AAs of VTN interacting with the flexible joint region of SERPINE1
  • two hemopexin-like domains
  • a RGD motif, integrin-binding sequence, regulating TGFB1-induced alveolar epithelial cell apoptosis
  • a heparin binding domain involved in the oligomerization process and such oligomerization reinforces the activity of VTN in cell adhesion and spreading
  • conjugated GlycoP
    mono polymer monomer , dimer
    isoforms Precursor precursor of 65 and 10kDa chains
    HOMOLOGY
    Homologene
    FAMILY pexin family
    CATEGORY immunity/defense , regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text secreted
    basic FUNCTION
  • inhibitor of the cytolytic action of the terminal complement cascade growth hormone-dependent serum factor with protease-inhibiting activity
  • modulating SHH response in central nervous system
  • VTN and SERPINE1 are proteins that interact in the circulatory system and pericellular region to regulate fibrinolysis, cell adhesion, and migration
  • beneficial effect of VTN on oligodendrocytic differentiation of human embryonic stem cells (hESCs)
  • is a multi-functional protein found predominantly as a monomer in blood and as an oligomer in the extracellular matrix
  • is a glycoprotein found in normal serum and pathological extracellular matrix
  • inhibits neutrophil apoptosis through activation of integrin-associated signaling pathways
  • plays a previously unrecognized role in regulating endothelial permeability via conformational- and integrin-dependent effects on CDH5 trafficking
  • is involved in the whole process of atherosclerosis
  • may be involved in the pathogenesis of early-onset severe preeclampsia (EOSP), by inducing an imbalance between coagulation and fibrinolysis
  • importance of VTN and its interaction with the PLAUR in tumor growth
  • inhibits efferocytosis through interactions with apoptotic cells as well as with macrophages
  • adhesion to VTN allows likely for the uncoupling of FBN1 fibril formation from downstream signaling events by reducing ITGB1/ITGA5 integrin activation and FBN1 fibril extension
  • importance of VTN in the regulation of angiogenesis induced by VEGFA
  • plays a significant role in the malignant growth of tumor
  • Dental Bud Stem Cells (DBSCs) differentiation toward osteoblastic lineage was enhanced when cells were grown on fibronectin (FN1), vitronectin (VTN), and osteopontin (SPP1)
  • promotes the progress of the initial differentiation stage of cerebellar granule cell precursors (CGCPs)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • several proteinase inhibitors of the serpin family inhibiting PAI1 activation mediating the anchorage of PAT1 to fibrin filaments and as such modulating fibrinotysis
  • PLAUR is a non-integrin vitronectin (VTN) cell adhesion receptor linked to the plasma membrane by a glycolipid anchor
  • proapoptotic function of SERPINE1 is mediated through vitronectin (VTN) inhibition
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in sera from patients with Joint hypermobility syndrome (JHS)
    Susceptibility to vascular disease (chronic or acute myocardial infarctus , or deep venous thrombosis)
    Variant & Polymorphism SNP
  • rs2227721 was associated with susceptibility to vascular disease
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerbone 
    may serve as a potential therapeutic target in osteosarcoma
    cancerdigestiveliver
    inhibition of VTN could potentially be applied for the treatment of hepatocellular carcinoma
    cancerreproductiveovary
    could represent a target for the development of anti-adhesive strategies to impede ovarian cancer dissemination
    ANIMAL & CELL MODELS