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Symbol VMA21 contributors: shn/npt - updated : 07/12/2009
HGNC name VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)
HGNC id 22082
Corresponding disease
MEAX myopathy with excessive autophagy
Location Xq28      Physical location : 150.565.656 - 150.577.835
Synonym name
  • VMA21 vacuolar H+-ATPase homolog
  • vacuolar ATPase assembly integral membrane protein VMA21
    • Synonym symbol(s) XMEA, MEAX, LOC203547, MGC125514, MGC125516, MGC131652
    DNA
    TYPE functioning gene
    STRUCTURE 12.13 kb     3 Exon(s)
    MAPPING cloned   linked   status
    Map cen - DXS8011 - DXS8103 - VMA21 - DXS8061 - DXS8087 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 4717 - 101 - Ramachandran 2009
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to Vma21, Mus musculus
    ortholog to VMA21, pan troglodytes
    Homologene
    FAMILY
  • VMA21 family
    • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum - an essential assembly chaperone of the V-ATPase,the principal mammalian proton pump complex - has a major role in autophagy, long-live protein degradation and vacuolation (Ramachandran 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism protein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MEAX
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS