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FLASH GENE
Symbol VIPR2 contributors: mct - updated : 23-09-2011
HGNC name vasoactive intestinal peptide receptor 2
HGNC id 12695
Location 7q36.3      Physical location : 158.820.866 - 158.937.649
Synonym symbol(s) VPAC2, FLJ16511
DNA
TYPE functioning gene
STRUCTURE 116.78 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Map cen - D7S22 - D7S98 - D7S68 - (3'- VIPR2 - 5') - D7S593 - D7S591 - D7S592 - D7S590 - D7S594 - qter
Authors MacKay (96)
Physical map
INSIG1 7q36 insulin induced gene 1 EN2 7q36.2 engrailed homolog 2 LOC392157 7 similar to RIKEN cDNA 9630008K15 gene MGC20460 7q36.3 hypothetical protein MGC20460 SHH 7q36 sonic hedgehog homolog (Drosophila) LOC389602 7 hypothetical gene supported by AK124321 LOC346305 7q36.3 similar to hypothetical protein Tb927.2.4050 LOC285890 7q36.3 hypothetical LOC285890 C7orf13 7q36 chromosome 7 open reading frame 13 RNF32 7q36 ring finger protein 32 C7orf2 7q36 chromosome 7 open reading frame 2 C7orf3 7q36 chromosome 7 open reading frame 3 HLXB9 7q36 homeo box HB9 LOC392158 7 similar to S-adenosylmethionine decarboxylase KIAA0010 7q36.3 ubiquitin-protein isopeptide ligase (E3) DNAJB6 7q36.3 DnaJ (Hsp40) homolog, subfamily B, member 6 LOC392159 7 similar to polycystic kidney disease 1-like 3 LOC389603 7 hypothetical gene supported by AK098637 PTPRN2 7q36 protein tyrosine phosphatase, receptor type, N polypeptide 2 LOC285872 7q36.3 hypothetical gene supported by AL833137 FLJ20311 7q36.3 hypothetical protein FLJ20311 KIAA1228 7q36.3 hypothetical protein FLJ20311 FLJ10300 7q36.3 hypothetical protein FLJ10300 LOC392160 7 LOC392160 LOC392161 7 LOC392161 VIPR2 7q36.3 vasoactive intestinal peptide receptor 2 LOC154822 7q36.3 hypothetical protein LOC154822 LOC392162 7 similar to 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 1640 - 438 - 2006 16934434
  • truncated isoform lacking the region in the third intracellumlar loop, the fourth extra-cellular loop and TM6-7
  • having a severe inability to activate adenylate-cyclase and produce cAMP
  • 13 - 3958 - 438 - 1999 10481065
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Nervousbrain   predominantly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    Nervouscentral  predominantly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    seven transmembrane segments (7TM)
    HOMOLOGY
    Homologene
    FAMILY secretin receptor superfamily, G protein coupled
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • presents an extranuclear localization
  • basic FUNCTION
  • responding to the pituitary adenylate cyclase activating polypeptide in stimulating cAMP production
  • VIPR2 and/or ADCYAPR1 receptor activation is involved in cutaneous active vasodilation in humans
  • dual role for VIPR1 and VIPR2 receptors in mediating the antiproliferative effects of VIP with VIPR2 appearing to play a more dominant role
  • VIP and its receptors (VIPR1, VIPR2) are involved in proliferation, survival, and differentiation in human breast cancer cells
  • VIP/VIPR2 system induces reactive astrocytosis and plays a key role in neuroprotection against excitotoxicity in neurological disorders
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with VIP and VIPR1 (expands the pool of symmetrically dividing postnatal dentate gyrus precursors via VIPR2 receptors or directs them toward a neuronal fate via VIPR1 receptors)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer as compared to non-tumor tissue (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS