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FLASH GENE
Symbol VIPR2 contributors: mct - updated : 13-09-2023
HGNC name vasoactive intestinal peptide receptor 2
HGNC id 12695
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Nervousbrain   predominantly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
Nervouscentral  predominantly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
seven transmembrane segments (7TM)
HOMOLOGY
Homologene
FAMILY secretin receptor superfamily, G protein coupled
CATEGORY receptor
SUBCELLULAR LOCALIZATION     plasma membrane
text
  • presents an extranuclear localization
  • basic FUNCTION
  • responding to the pituitary adenylate cyclase activating polypeptide in stimulating cAMP production
  • VIPR2 and/or ADCYAPR1 receptor activation is involved in cutaneous active vasodilation in humans
  • dual role for VIPR1 and VIPR2 receptors in mediating the antiproliferative effects of VIP with VIPR2 appearing to play a more dominant role
  • VIP and its receptors (VIPR1, VIPR2) are involved in proliferation, survival, and differentiation in human breast cancer cells
  • VIP/VIPR2 system induces reactive astrocytosis and plays a key role in neuroprotection against excitotoxicity in neurological disorders
  • controls breast tumor growth by regulating the cAMP/PKA/ERK signaling pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with VIP and VIPR1 (expands the pool of symmetrically dividing postnatal dentate gyrus precursors via VIPR2 receptors or directs them toward a neuronal fate via VIPR1 receptors)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer as compared to non-tumor tissue (
    tumoral     --low  
    in esophageal squamous cell carcinoma (ESCC)
    tumoral     --over  
    excessive expression of VIPR2 may lead to an exacerbation of breast carcinoma
    Susceptibility
  • to chromosome rearrangements
  • to age-related macular degeneration (AMD)
  • to myopia
  • Variant & Polymorphism other
  • low-copy repeat (LCR) sequences in VIPR2 can mediate the formation of inversions and more complex structural rearrangements through non-allelic homologous recombination
  • rs3793217 associated with AMD
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS