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FLASH GENE

Symbol

VGLL2

contributors: mct - updated : 06-07-2021

HGNC name	vestigial like 2 (Drosophila)
HGNC id	20232

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6q22.1      Physical location : 117.586.720 - 117.594.727
Synonym name	transcription cofactor vestigial-like 2
	SID (scalloped interaction domain)-containing protein
	Vestigial and Tondu related protein 1
Synonym symbol(s)	VGL2, VITO1

DNA

TYPE	functioning gene
STRUCTURE	8.01 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_153453 3 - 1709 NP_703154 - 143 - 2020 33060790 NM_182645 4 - 2231 NP_872586 33.4 317 - 2020 33060790

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Nervous brain

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text	placenta, the differentiating somites and branchial arches during embryogenesis

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	SID (scalloped interaction) domain
	a single TDU motif

HOMOLOGY

Homologene

FAMILY

CATEGORY

motor/contractile , protooncogene

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus
text	during muscle differentiation, VGLL2 mRNA levels increase and VGLL2 protein translocates from the cytoplasm to the nucleus

basic FUNCTION	playing an important role in the muscle differentiation and the development of skeletal muscles and of pharyngeal clefts/Rathke's pouch derived structures
	VGLL2 is an essential regulator of the switch towards a slow-contractile phenotype and oxidative metabolism during chronic overload
	VGLL2 plays an important role for functional adaptation of skeletal muscle to chronic overload

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	a cofactor of TEF-1 and MEF2
	VGLL2 may be both directly and indirectly involved in the programing of slow muscle fibers through the formation of the VGLL2-TEAD complex

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion       VGLL2/NCOA2 fusions in pediatric spindle cell/sclerosing rhabdomyosarcoma

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Vgll2 (-/-) mice presented an increased number of fast-twitch type IIb fibers and exhibited a down-regulation of slow type I myosin heavy chain (MyHC) gene, Myh7, which resulted in exercise intolerance