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FLASH GENE
Symbol VGLL2 contributors: mct - updated : 06-07-2021
HGNC name vestigial like 2 (Drosophila)
HGNC id 20232
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Nervousbrain    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text placenta, the differentiating somites and branchial arches during embryogenesis
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • SID (scalloped interaction) domain
  • a single TDU motif
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY motor/contractile , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text during muscle differentiation, VGLL2 mRNA levels increase and VGLL2 protein translocates from the cytoplasm to the nucleus
    basic FUNCTION
  • playing an important role in the muscle differentiation and the development of skeletal muscles and of pharyngeal clefts/Rathke's pouch derived structures
  • VGLL2 is an essential regulator of the switch towards a slow-contractile phenotype and oxidative metabolism during chronic overload
  • VGLL2 plays an important role for functional adaptation of skeletal muscle to chronic overload
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • a cofactor of TEF-1 and MEF2
  • VGLL2 may be both directly and indirectly involved in the programing of slow muscle fibers through the formation of the VGLL2-TEAD complex
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    VGLL2/NCOA2 fusions in pediatric spindle cell/sclerosing rhabdomyosarcoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Vgll2 (-/-) mice presented an increased number of fast-twitch type IIb fibers and exhibited a down-regulation of slow type I myosin heavy chain (MyHC) gene, Myh7, which resulted in exercise intolerance