Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol VEZF1 contributors: mct/npt/pgu - updated : 05-06-2013
HGNC name vascular endothelial zinc finger 1
HGNC id 12949
Location 17q22      Physical location : 56.048.909 - 56.065.615
Synonym name
  • zinc finger protein 161
  • putative transcription factor DB1
  • Synonym symbol(s) DB1, ZNF161
    DNA
    TYPE functioning gene
    STRUCTURE 16.71 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 4652 - 521 - 1994 8035792
    - - 4800 - - - 1994 8035792
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel     Homo sapiensAdult
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six C2H2-type zinc finger motifs tandemly repeated
  • four potential N-glycosylation sites
  • VEZF1-specific binding sites are sufficient to mediate demethylation and protection of the APRT gene promoter from DNA methylation
  • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to murine Vezf1
    homolog to Drosophila CG1832
    homolog to C.elegans C55B7.12
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • mediating TAX transactivation of IL-3
  • transcription factor that is expressed in endothelial cells and plays a requisite role in the regulation of angiogenesis
  • plays a widespread role in the control of DNA methylation
  • regulates genomic DNA methylation through its effects on expression of DNA methyltransferase DNMT3B
  • implicated in the development of the blood vascular and lymphatic system
  • early zinc finger transcription factor that is essential for normal vascular development and functions in a dose-dependent manner
  • nvolved in early differentiation processes of the vasculature by regulating cell differentiation, proliferation, and ECM distribution and deposition
  • plays multiple roles important for embryonic development
  • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS immunity/defense
    text
  • cellular defense response
  • activator
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • binding to the interleukin-3 promoter (to the CT/GC-rich regon) in cooperation with TAX
  • MT1A is a downstream target of VEZF1 in endothelial cells and is involved in the regulation of angiogenesis
  • interacts with the CGI promoter of the DHFR gene
  • VEZF1 interacts with MORF4L1/MRGBP, a protein that recognizes H3K36 trimethylation, consistent with the role of histone modifications at alternatively spliced sites
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • in Vezf1(-/-) mouse embryonic stem (mES) cells, widespread changes in gene-expression profiles, including decreased expression of the full-length active isoform of Dnmt3b methyltransferase and concomitant genome-wide reduction in DNA methylation