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FLASH GENE

Symbol

VEZF1

contributors: mct/npt/pgu - updated : 05-06-2016

HGNC name	vascular endothelial zinc finger 1
HGNC id	12949

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	16.71 kb     6 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_007146 6 - 4652 NP_009077 - 521 - 1994 8035792 variant 2 - - 4800 isoform 2 - - - 1994 8035792

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel         Homo sapiens Adult Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Cardiovascular endothelial cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	six C2H2-type zinc finger motifs tandemly repeated
	four potential N-glycosylation sites
	VEZF1-specific binding sites are sufficient to mediate demethylation and protection of the APRT gene promoter from DNA methylation

conjugated

MetalloP

HOMOLOGY

interspecies	homolog to murine Vezf1
	homolog to Drosophila CG1832
	homolog to C.elegans C55B7.12

Homologene

FAMILY

krueppel C2H2-type zinc-finger protein family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	mediating TAX transactivation of IL-3
	transcription factor that is expressed in endothelial cells and plays a requisite role in the regulation of angiogenesis
	plays a widespread role in the control of DNA methylation
	regulates genomic DNA methylation through its effects on expression of DNA methyltransferase DNMT3B
	implicated in the development of the blood vascular and lymphatic system
	early zinc finger transcription factor that is essential for normal vascular development and functions in a dose-dependent manner
	nvolved in early differentiation processes of the vasculature by regulating cell differentiation, proliferation, and ECM distribution and deposition
	plays multiple roles important for embryonic development

CELLULAR PROCESS	cell life, differentiation
	cell life, proliferation/growth
	nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

immunity/defense

text	cellular defense response
	activator

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	Zn2+

protein	binding to the interleukin-3 promoter (to the CT/GC-rich regon) in cooperation with TAX
	MT1A is a downstream target of VEZF1 in endothelial cells and is involved in the regulation of angiogenesis
	interacts with the CGI promoter of the DHFR gene
	VEZF1 interacts with MORF4L1/MRGBP, a protein that recognizes H3K36 trimethylation, consistent with the role of histone modifications at alternatively spliced sites
	SETBP1 is a crucial target of TRIM29, and TRIM29 facilitated SETBP1 transcriptional activation via the VEZF1 transcription factor

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

in Vezf1(-/-) mouse embryonic stem (mES) cells, widespread changes in gene-expression profiles, including decreased expression of the full-length active isoform of Dnmt3b methyltransferase and concomitant genome-wide reduction in DNA methylation