Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

VAC14

contributors: mct - updated : 25-01-2011

HGNC name	Vac14 homolog (S. cerevisiae)
HGNC id	25507

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	16q22.1      Physical location : 70.721.343 - 70.835.061
Synonym name	Tax1 (human T-cell leukemia virus type I) binding protein 2
Synonym symbol(s)	TAX1BP2, TRX, ArPIKfyve, FLJ10305, FLJ36622, MGC149815

DNA

TYPE	functioning gene
STRUCTURE	113.00 kb     19 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_018052 19 - 3107 NP_060522 - 782 - 2007 17556371

EXPRESSION

Type

widely

constitutive of

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   moderately   liver       highly Lymphoid/Immune thymus       highly Reproductive female system uterus cervix   predominantly   female system ovary     moderately   male system testis     moderately Skin/Tegument skin       highly Visual eye       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Nervous peripherous

cell lineage
cell lines
fluid/secretion	blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES		Hydrophilic
STRUCTURE

motifs/domains

predominantly hydrophilic in its C-terminal region

HOMOLOGY

interspecies	ortholog to rattus Vac14
	homolog to murine Vac14

Homologene

FAMILY

CATEGORY

regulatory , signaling

SUBCELLULAR LOCALIZATION

basic FUNCTION	regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate
	exerts an effect as a scaffold for the PI(3,5)P(2) regulatory complex by direct contact with the known regulators of PI(3,5)P(2): FIG4, PIKFYVE, VIPI1
	might control FIG4 protein degradation
	enhances FIG4 abundance by attenuating FIG4 proteasome-dependent degradation
	essential role for the VAC14 homocomplex in controlling PtdIns(3,5)P2 levels

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	with FIG4 and PIKFYVE, constitute a single multiprotein complex organized by the PIKFYVE regulator VAC14 and its ability to homodimerize
	VAC14/PIKFYVE, a multimeric scaffolding adaptor protein coordinates synthesis and turnover of PtdIns(3,5)P2

INTERACTION

DNA

RNA

small molecule

protein	Tax1
	interaction between the PDZ domain of NOS1 and VAC14

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS