SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,organelle,endosome
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basic FUNCTION
| regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate |
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exerts an effect as a scaffold for the PI(3,5)P(2) regulatory complex by direct contact with the known regulators of PI(3,5)P(2): FIG4, PIKFYVE, VIPI1 |
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might control FIG4 protein degradation |
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enhances FIG4 abundance by attenuating FIG4 proteasome-dependent degradation |
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essential role for the VAC14 homocomplex in controlling PtdIns(3,5)P2 levels |
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acts in a complex with the lipid kinase PIKFYVE and its counteracting phosphatase FIG4, regulating the interconversion of phosphatidylinositol-3-phosphate to phosphatidylinositol-3,5-bisphosphate |