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FLASH GENE
Symbol VAC14 contributors: mct - updated : 25-08-2016
HGNC name Vac14 homolog (S. cerevisiae)
HGNC id 25507
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon moderately
 liver   highly
Lymphoid/Immunethymus   highly
Reproductivefemale systemuteruscervix predominantly
 female systemovary  moderately
 male systemtestis  moderately
Skin/Tegumentskin   highly
Visualeye   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Nervousperipherous   
cell lineage
cell lines
fluid/secretion blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophilic
STRUCTURE
motifs/domains
  • predominantly hydrophilic in its C-terminal region
  • HOMOLOGY
    interspecies ortholog to rattus Vac14
    homolog to murine Vac14
    Homologene
    FAMILY
    CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate
  • exerts an effect as a scaffold for the PI(3,5)P(2) regulatory complex by direct contact with the known regulators of PI(3,5)P(2): FIG4, PIKFYVE, VIPI1
  • might control FIG4 protein degradation
  • enhances FIG4 abundance by attenuating FIG4 proteasome-dependent degradation
  • essential role for the VAC14 homocomplex in controlling PtdIns(3,5)P2 levels
  • acts in a complex with the lipid kinase PIKFYVE and its counteracting phosphatase FIG4, regulating the interconversion of phosphatidylinositol-3-phosphate to phosphatidylinositol-3,5-bisphosphate
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • with FIG4 and PIKFYVE, constitute a single multiprotein complex organized by the PIKFYVE regulator VAC14 and its ability to homodimerize
  • VAC14/PIKFYVE, a multimeric scaffolding adaptor protein coordinates synthesis and turnover of PtdIns(3,5)P2
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • Tax1
  • interaction between the PDZ domain of NOS1 and VAC14
  • VAC14, PI(3,5)P(2) and/or PI(5)P play a role in controlling postsynaptic function via regulation of endocytic cycling of AMPA receptors
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SNDC
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS