basic FUNCTION
| implicated in mediating protein-protein interactions |
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player to the emerging picture of the autophagy network, under-scoring the importance of the coordinated activity between BCL2 and UVRAG in the regulation of Beclin 1-PI3KC3-mediated autophagy and tumor cell control |
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regulator of autophagosome formation, also promoting autophagosome maturation by recruiting the fusion machinery of the late endosome |
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phosphatidylinositol 3-kinase class III sub-complex containing PIK3R4, PIK3C3, BECN1, UVRAG and SH3GLB1 regulates cytokinesis and degradative endocytic traffic |
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activates PI3KC3 and C-VPS/HOPS, a guanine nucleotide exchange factor that catalyzes the exchange of GDP for GTP on RAB7A |
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is a tumor suppressor involved in autophagy, and plays an integral role in UV-induced DNA damage repair |