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FLASH GENE
Symbol UVRAG contributors: mct/npt - updated : 30-05-2015
HGNC name UV radiation resistance associated gene
HGNC id 12640
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 5166 78.1 699 - Liang (2007)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
Endocrinepancreas   highly
Lymphoid/Immunethymus   highly
Nervousbrain   highly
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connective    
Lymphoid    
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, fetal
Text presomite stage embryo, fetal eye
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one coiled coil domain
  • one C2 domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text perhaps forming part of the cytoskeleton
    basic FUNCTION
  • implicated in mediating protein-protein interactions
  • player to the emerging picture of the autophagy network, under-scoring the importance of the coordinated activity between BCL2 and UVRAG in the regulation of Beclin 1-PI3KC3-mediated autophagy and tumor cell control
  • regulator of autophagosome formation, also promoting autophagosome maturation by recruiting the fusion machinery of the late endosome
  • phosphatidylinositol 3-kinase class III sub-complex containing PIK3R4, PIK3C3, BECN1, UVRAG and SH3GLB1 regulates cytokinesis and degradative endocytic traffic
  • activates PI3KC3 and C-VPS/HOPS, a guanine nucleotide exchange factor that catalyzes the exchange of GDP for GTP on RAB7A
  • is a tumor suppressor involved in autophagy, and plays an integral role in UV-induced DNA damage repair
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • essential component of the Beclin1-PI(3)KC3 lipid kinase complex that is an important signalling checkpoint for autophagy and tumour-cell growth
  • SCOC forms a starvation-sensitive trimeric complex with UVRAG (UV radiation resistance associated gene) and FEZ1
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with RAB7A, and RUBICON (GTP-bound RAB7A competes with UVRAG for RUBICON binding)
  • BECN1 coiled coil domain (CCD) serves as an interaction platform for assembly of distinct ATG14- and UVRAG-containing complexes to modulate PIK3C3 activity
  • SLAMF1 interacts with the class III PIK3C3 in a complex with BECN1 and UVRAG
  • UVRAG is a regulator of CRL4(DDB2)-mediated NER, suggesting that its expression levels may influence melanoma predisposition
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HTX11
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS