Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

UTS2R

contributors: mct - updated : 19-12-2016

HGNC name	urotensin 2 receptor
HGNC id	4468

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17q25.3      Physical location : 80.332.200 - 80.333.369
Synonym name	G protein-coupled receptor 14
Synonym symbol(s)	GPR14, UR-II-R, UTR, UTR2, UR-2-R

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem
STRUCTURE	1.17 kb     1 Exon(s)

regulatory sequence	Promoter
	Binding site   enhancer
text structure	promoter revealed the presence of NF-kappaB-binding sites involved in the stimulation of UT receptor gene expression by LPS (Segain 2007)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_018949 1 - 1170 NP_061822 42 389 - 2009 19001524

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel         Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Cardiovascular endothelial cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven transmembrane domains

conjugated

GlycoP

HOMOLOGY

interspecies	ortholog to murine Uts2r
	ortholog to rattus Uts2r

Homologene

FAMILY

G-protein coupled receptor 1 family

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endosome
text	integral to membrane

basic FUNCTION	mobilizing intracellular calcium in response to urotensin 2 for arterial constriction
	playing a possible role in the pathophysiology of atherosclerosis
	its activation leads to an increase in Ca(2+), activation of phospholipase A(2) (PLA(2)) and an increase in arachidonic acid
	intrahepatic UTS2/UTS2R system has an important pathophysiological role in cirrhosis and portal hypertension
	appears to be involved in the regulation of colon cancer cell invasion and motility
	is likely involved in the regulation of motility, invasion and proliferation of bladder cancer cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cardiovascular

text	circulation

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	binding its ligand UTS2 (initiation site of extracellular loop -III, as well as the upstream portion of helix VII, would be involved in agonist binding and allow to propose points of interaction in the ligand-receptor complex)
	UTS2R activation stimulates RGS2 recruitment to glomerular mesangial cells (GMCs) plasma membrane as a negative feedback mechanism to regulate UTS2R signaling

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	can be considered a prognostic marker in human prostate adenocarcinoma patients
Therapy target
	System Type Disorder Pubmed miscelleaneous urinary   UTS2/UTS2R pathway may represent a novel therapeutical target in erectile dysfunction cancer digestive colon may function as a target for therapeutic intervention in colon cancer

ANIMAL & CELL MODELS