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FLASH GENE
Symbol UTS2R contributors: mct - updated : 19-12-2016
HGNC name urotensin 2 receptor
HGNC id 4468
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel     Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane domains
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Uts2r
    ortholog to rattus Uts2r
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    text integral to membrane
    basic FUNCTION
  • mobilizing intracellular calcium in response to urotensin 2 for arterial constriction
  • playing a possible role in the pathophysiology of atherosclerosis
  • its activation leads to an increase in Ca(2+), activation of phospholipase A(2) (PLA(2)) and an increase in arachidonic acid
  • intrahepatic UTS2/UTS2R system has an important pathophysiological role in cirrhosis and portal hypertension
  • appears to be involved in the regulation of colon cancer cell invasion and motility
  • is likely involved in the regulation of motility, invasion and proliferation of bladder cancer cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cardiovascular
    text
  • circulation
  • PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding its ligand UTS2 (initiation site of extracellular loop -III, as well as the upstream portion of helix VII, would be involved in agonist binding and allow to propose points of interaction in the ligand-receptor complex)
  • UTS2R activation stimulates RGS2 recruitment to glomerular mesangial cells (GMCs) plasma membrane as a negative feedback mechanism to regulate UTS2R signaling
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • can be considered a prognostic marker in human prostate adenocarcinoma patients
  • Therapy target
    SystemTypeDisorderPubmed
    miscelleaneousurinary 
    UTS2/UTS2R pathway may represent a novel therapeutical target in erectile dysfunction
    cancerdigestivecolon
    may function as a target for therapeutic intervention in colon cancer
    ANIMAL & CELL MODELS